PE2R4_PANTR
ID PE2R4_PANTR Reviewed; 490 AA.
AC Q95KZ0;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Prostaglandin E2 receptor EP4 subtype;
DE Short=PGE receptor EP4 subtype;
DE Short=PGE2 receptor EP4 subtype;
DE AltName: Full=Prostanoid EP4 receptor;
GN Name=PTGER4;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Smock S.L., Castleberry T.A., Lu B., Owen T.A.;
RT "Pan troglodytes prostaglandin E2 subtype EP4 receptor.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this
CC receptor is mediated by G(s) proteins that stimulate adenylate cyclase.
CC Has a relaxing effect on smooth muscle. May play an important role in
CC regulating renal hemodynamics, intestinal epithelial transport, adrenal
CC aldosterone secretion, and uterine function (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FEM1A. {ECO:0000250|UniProtKB:P35408}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylation mediates agonist-mediated desensitization by
CC promoting cytoplasmic retention. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY052641; AAL15039.1; -; mRNA.
DR RefSeq; NP_001009078.1; NM_001009078.1.
DR RefSeq; XP_009447464.1; XM_009449189.2.
DR AlphaFoldDB; Q95KZ0; -.
DR SMR; Q95KZ0; -.
DR STRING; 9598.ENSPTRP00000028838; -.
DR PaxDb; Q95KZ0; -.
DR Ensembl; ENSPTRT00000031222; ENSPTRP00000028838; ENSPTRG00000016819.
DR GeneID; 450195; -.
DR KEGG; ptr:450195; -.
DR CTD; 5734; -.
DR VGNC; VGNC:4139; PTGER4.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244902; -.
DR HOGENOM; CLU_045991_0_2_1; -.
DR InParanoid; Q95KZ0; -.
DR OMA; PTIPTVM; -.
DR OrthoDB; 972015at2759; -.
DR TreeFam; TF324982; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000016819; Expressed in thymus and 15 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004957; F:prostaglandin E receptor activity; ISS:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0001818; P:negative regulation of cytokine production; IEA:Ensembl.
DR GO; GO:2000420; P:negative regulation of eosinophil extravasation; ISS:UniProtKB.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0033624; P:negative regulation of integrin activation; ISS:UniProtKB.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0030278; P:regulation of ossification; IEA:Ensembl.
DR GO; GO:0051492; P:regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0009624; P:response to nematode; IEA:Ensembl.
DR GO; GO:0042093; P:T-helper cell differentiation; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001758; Prost_EP4_rcpt.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR InterPro; IPR001244; Prostglndn_DP_rcpt.
DR PANTHER; PTHR11866; PTHR11866; 1.
DR PANTHER; PTHR11866:SF6; PTHR11866:SF6; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00428; PROSTAGLNDNR.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00586; PRSTNOIDEP4R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..490
FT /note="Prostaglandin E2 receptor EP4 subtype"
FT /id="PRO_0000070066"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..297
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..314
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..334
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..490
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 359..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 376
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P35408"
FT MOD_RES 379
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P35408"
FT MOD_RES 381
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P35408"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P35408"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 92..170
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 490 AA; 53304 MW; 2074ACAE9CBF87D0 CRC64;
MSTPGVNASA SLSPDRLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK ETTFYTLVCG
LAVTDLLGTL LVSPVTIATY MKGQWPGGQP LCEYSTFILL FFSLSGLSII CAMSVERYLA
INHAYFYSHY VDKRLAGLTL FAVYASNVLF CALPNMGLGS SRLQYPDTWC FIDWTTNVTA
HAAYSYMYAG FSSFLILATV LCNVLVCGAL LRMHRQFMRR TSLGTEQHHA AAAAVTSVAS
RGHPAASPAL PRLSDFRRRR SFRRIAGAEI QMVILLIATS LVVLICSIPL VVRVFVNQLY
QPSLEREVSK NPDLQAIRIA SVNPILDPWI YILLRKTVLS KAIEKIKCLF CRIGGSRRER
SGQHCSDSQR TSSAMSGHSR SFISRELKEI SSTSQTLLPD LSLPDLSENG LGGRNLLPGV
PGMGLAQEDT TSLRTLRISE TSDSSQGQDS ESVLLVDEAG GSGRAGPAPK GSSLQVTFPS
ETLNLSEKCI
