ID   PE35_MYCTO              Reviewed;          98 AA.
AC   P9WIG6; L0TGV1; Q79F93; Q8VIR8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=PE family immunomodulator PE35 {ECO:0000250|UniProtKB:P9WIG7};
GN   Name=PE35; OrderedLocusNames=MT3986;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Plays a major role in RD1-associated pathogenesis, and may
CC       contribute to the establishment and maintenance of M.tuberculosis
CC       infection. Together with PPE68, stimulates the secretion of IL-10 and
CC       MCP-1 from human macrophages, via the interaction with human Toll-like
CC       receptor 2 (TLR2). {ECO:0000250|UniProtKB:P9WIG7}.
CC   -!- SUBUNIT: Interacts with PPE68. PE35/PPE68 complex interacts with human
CC       TLR2. {ECO:0000250|UniProtKB:P9WIG7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WIG7}. Cell
CC       surface {ECO:0000250|UniProtKB:P9WIG7}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK48354.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK48354.1; ALT_INIT; Genomic_DNA.
DR   PIR; F70802; F70802.
DR   RefSeq; WP_003399870.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIG6; -.
DR   SMR; P9WIG6; -.
DR   EnsemblBacteria; AAK48354; AAK48354; MT3986.
DR   KEGG; mtc:MT3986; -.
DR   PATRIC; fig|83331.31.peg.4288; -.
DR   HOGENOM; CLU_173258_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..98
FT                   /note="PE family immunomodulator PE35"
FT                   /id="PRO_0000428010"
FT   DOMAIN          1..90
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  9799 MW;  DAEB9988A8BFFBB7 CRC64;
     MEKMSHDPIA ADIGTQVSDN ALHGVTAGST ALTSVTGLVP AGADEVSAQA ATAFTSEGIQ
     LLASNASAQD QLHRAGEAVQ DVARTYSQID DGAAGVFA