ID   PE38_NPVAC              Reviewed;         321 AA.
AC   P23801;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   23-FEB-2022, entry version 83.
DE   RecName: Full=Major immediate early protein;
DE   AltName: Full=PE-38;
GN   Name=PE38;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E;
RX   PubMed=1987375; DOI=10.1128/jvi.65.2.805-812.1991;
RA   Krappa R., Knebel-Moersdorf D.;
RT   "Identification of the very early transcribed baculovirus gene PE-38.";
RL   J. Virol. 65:805-812(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [3]
RP   FUNCTION.
RX   PubMed=8337840; DOI=10.1006/viro.1993.1422;
RA   Lu A., Carstens E.B.;
RT   "Immediate-early baculovirus genes transactivate the p143 gene promoter of
RT   Autographa californica nuclear polyhedrosis virus.";
RL   Virology 195:710-718(1993).
RN   [4]
RP   FUNCTION.
RX   PubMed=7972036; DOI=10.1073/pnas.91.23.11212;
RA   Kool M., Ahrens C.H., Goldbach R.W., Rohrmann G.F., Vlak J.M.;
RT   "Identification of genes involved in DNA replication of the Autographa
RT   californica baculovirus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11212-11216(1994).
RN   [5]
RP   SUBCELLULAR LOCATION.
RX   PubMed=7636971; DOI=10.1128/jvi.69.9.5287-5293.1995;
RA   Krappa R., Roncarati R., Knebel-Moersdorf D.;
RT   "Expression of PE38 and IE2, viral members of the C3HC4 finger family,
RT   during baculovirus infection: PE38 and IE2 localize to distinct nuclear
RT   regions.";
RL   J. Virol. 69:5287-5293(1995).
RN   [6]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10400766; DOI=10.1128/jvi.73.8.6691-6699.1999;
RA   Prikhod'ko E.A., Miller L.K.;
RT   "The baculovirus PE38 protein augments apoptosis induced by transactivator
RT   IE1.";
RL   J. Virol. 73:6691-6699(1999).
RN   [7]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11262179; DOI=10.1006/excr.2000.5081;
RA   Murges D., Quadt I., Schroeer J., Knebel-Moersdorf D.;
RT   "Dynamic nuclear localization of the baculovirus proteins IE2 and PE38
RT   during the infection cycle: the promyelocytic leukemia protein colocalizes
RT   with IE2.";
RL   Exp. Cell Res. 264:219-232(2001).
CC   -!- FUNCTION: Plays some regulatory role in both viral DNA replication and
CC       transcriptional transactivation. {ECO:0000269|PubMed:10400766,
CC       ECO:0000269|PubMed:7972036, ECO:0000269|PubMed:8337840}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:10400766,
CC       ECO:0000269|PubMed:11262179, ECO:0000269|PubMed:7636971}.
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DR   EMBL; M62488; AAA46733.1; -; Genomic_DNA.
DR   EMBL; L22858; AAA66783.1; -; Genomic_DNA.
DR   PIR; A43681; A43681.
DR   PIR; C72869; C72869.
DR   RefSeq; NP_054184.1; NC_001623.1.
DR   SMR; P23801; -.
DR   GeneID; 1403986; -.
DR   KEGG; vg:1403986; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   DNA replication; DNA-binding; Early protein; Host nucleus; Metal-binding;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Viral DNA replication; Zinc; Zinc-finger.
FT   CHAIN           1..321
FT                   /note="Major immediate early protein"
FT                   /id="PRO_0000056347"
FT   ZN_FING         86..139
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          228..249
FT                   /note="Leucine-zipper"
FT   CONFLICT        291
FT                   /note="G -> R (in Ref. 1; AAA46733)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   321 AA;  37425 MW;  4D5ACACB6291A60C CRC64;
     MPRDTNNRHR STPYERPTLE DLRRQLQDNL DSINRRDRMQ EEQEENLRYQ VRRRQRQNQL
     RSIQMEQQRM MAELNNEPVI NFKFECSVCL ETYSQQSNDT CPFLIPTTCD HGFCFKCVIN
     LQSNAMNIPH STVCCPLCNT QVKMWRSLKP NAVVTCKFYK KTQERVPPVQ QYKNIIKVLQ
     ERSVISVEDN DNNCDINMEN QAKIAALEAE LEEEKNHSDQ VASENRQLIE ENTRLNEQIQ
     ELQHQVRTLV PQRGITVNQQ IGRDDSAPAE LNERFRSLVY STISELFIEN GVHSIQNYVY
     AGTSAASSCD VNVTVNFGFE N