ID   PEA15_PONAB             Reviewed;         130 AA.
AC   Q5R529;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Astrocytic phosphoprotein PEA-15;
DE   AltName: Full=15 kDa phosphoprotein enriched in astrocytes;
GN   Name=PEA15;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Blocks Ras-mediated inhibition of integrin activation and
CC       modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by
CC       retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-
CC       mediated CASP8 activity and apoptosis. Regulates glucose transport by
CC       controlling both the content of SLC2A1 glucose transporters on the
CC       plasma membrane and the insulin-dependent trafficking of SLC2A4 from
CC       the cell interior to the surface (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds RPS6KA3, MAPK3 and MAPK1. Interacts with CASP8 and FADD.
CC       Transient interaction with PLD1 and PLD2 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with microtubules.
CC       {ECO:0000250}.
CC   -!- PTM: Phosphorylated by protein kinase C and calcium-calmodulin-
CC       dependent protein kinase. These phosphorylation events are modulated by
CC       neurotransmitters or hormones (By similarity). {ECO:0000250}.
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DR   EMBL; CR861049; CAH93137.1; -; mRNA.
DR   EMBL; CR926078; CAI29705.1; -; mRNA.
DR   RefSeq; NP_001127112.1; NM_001133640.1.
DR   AlphaFoldDB; Q5R529; -.
DR   BMRB; Q5R529; -.
DR   SMR; Q5R529; -.
DR   STRING; 9601.ENSPPYP00000000745; -.
DR   Ensembl; ENSPPYT00000000774; ENSPPYP00000000745; ENSPPYG00000000638.
DR   GeneID; 100174153; -.
DR   KEGG; pon:100174153; -.
DR   CTD; 8682; -.
DR   eggNOG; KOG3573; Eukaryota.
DR   GeneTree; ENSGT00390000000230; -.
DR   HOGENOM; CLU_159419_0_0_1; -.
DR   InParanoid; Q5R529; -.
DR   OrthoDB; 1425994at2759; -.
DR   TreeFam; TF332405; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0000165; P:MAPK cascade; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd08338; DED_PEA15; 1.
DR   Gene3D; 1.10.533.10; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR029546; PEA15_DED.
DR   Pfam; PF01335; DED; 1.
DR   SMART; SM00031; DED; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   PROSITE; PS50168; DED; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Phosphoprotein; Reference proteome; Sugar transport;
KW   Transport.
FT   CHAIN           1..130
FT                   /note="Astrocytic phosphoprotein PEA-15"
FT                   /id="PRO_0000252681"
FT   DOMAIN          3..81
FT                   /note="DED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00065"
FT   REGION          98..107
FT                   /note="Microtubule-binding"
FT                   /evidence="ECO:0000255"
FT   REGION          122..129
FT                   /note="Microtubule-binding"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         61
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15121"
FT   MOD_RES         90
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62048"
FT   MOD_RES         104
FT                   /note="Phosphoserine; by PKC"
FT                   /evidence="ECO:0000250|UniProtKB:Q62048"
FT   MOD_RES         116
FT                   /note="Phosphoserine; by CaMK2"
FT                   /evidence="ECO:0000250|UniProtKB:Q62048"
SQ   SEQUENCE   130 AA;  15040 MW;  8D0F93A40B299FB2 CRC64;
     MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL
     SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI
     IKLAPPPKKA