PEB1A_CAMJE
ID PEB1A_CAMJE Reviewed; 259 AA.
AC Q0P9X8; P45678;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Major cell-binding factor;
DE AltName: Full=CBF1;
DE AltName: Full=PEB1;
DE Flags: Precursor;
GN Name=peb1A; OrderedLocusNames=Cj0921c;
OS Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS 11168).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=192222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700819 / NCTC 11168;
RX PubMed=10688204; DOI=10.1038/35001088;
RA Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA Barrell B.G.;
RT "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT reveals hypervariable sequences.";
RL Nature 403:665-668(2000).
RN [2]
RP PROTEIN SEQUENCE OF 27-53.
RX PubMed=1885571; DOI=10.1016/s0021-9258(18)55306-0;
RA Pei Z., Ellison R.T. III, Blaser M.J.;
RT "Identification, purification, and characterization of major antigenic
RT proteins of Campylobacter jejuni.";
RL J. Biol. Chem. 266:16363-16369(1991).
CC -!- FUNCTION: Common antigen and a major cell adherence molecule. Most
CC probably involved, with PEB1C, in a binding-protein-dependent transport
CC system for an amino acid. May be involved in binding to intestinal
CC cells.
CC -!- SUBCELLULAR LOCATION: Cell surface.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 3 family.
CC {ECO:0000305}.
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DR EMBL; AL111168; CAL35041.1; -; Genomic_DNA.
DR PIR; A48518; A48518.
DR RefSeq; WP_002853252.1; NC_002163.1.
DR RefSeq; YP_002344319.1; NC_002163.1.
DR PDB; 2V25; X-ray; 1.49 A; A/B=1-259.
DR PDBsum; 2V25; -.
DR AlphaFoldDB; Q0P9X8; -.
DR SMR; Q0P9X8; -.
DR IntAct; Q0P9X8; 90.
DR STRING; 192222.Cj0921c; -.
DR TCDB; 3.A.1.3.16; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q0P9X8; -.
DR PRIDE; Q0P9X8; -.
DR EnsemblBacteria; CAL35041; CAL35041; Cj0921c.
DR GeneID; 906008; -.
DR KEGG; cje:Cj0921c; -.
DR PATRIC; fig|192222.6.peg.905; -.
DR eggNOG; COG0834; Bacteria.
DR HOGENOM; CLU_019602_18_4_7; -.
DR OMA; YIAGIRM; -.
DR EvolutionaryTrace; Q0P9X8; -.
DR PRO; PR:Q0P9X8; -.
DR Proteomes; UP000000799; Chromosome.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR InterPro; IPR018313; SBP_3_CS.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR Pfam; PF00497; SBP_bac_3; 1.
DR SMART; SM00062; PBPb; 1.
DR PROSITE; PS01039; SBP_BACTERIAL_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome; Signal;
KW Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000269|PubMed:1885571"
FT CHAIN 27..259
FT /note="Major cell-binding factor"
FT /id="PRO_0000031772"
FT HELIX 30..37
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 40..44
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:2V25"
FT TURN 49..51
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:2V25"
FT TURN 56..58
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 61..63
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 64..77
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 82..87
FT /evidence="ECO:0007829|PDB:2V25"
FT TURN 90..92
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 93..98
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 103..105
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 113..116
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 119..121
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 125..135
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 136..138
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 143..145
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 150..154
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 159..169
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 175..181
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 182..190
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 193..200
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 201..204
FT /evidence="ECO:0007829|PDB:2V25"
FT TURN 205..207
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 212..214
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 220..224
FT /evidence="ECO:0007829|PDB:2V25"
FT STRAND 227..229
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 233..245
FT /evidence="ECO:0007829|PDB:2V25"
FT HELIX 247..256
FT /evidence="ECO:0007829|PDB:2V25"
SQ SEQUENCE 259 AA; 28178 MW; DA132ECE87BBCBD5 CRC64;
MVFRKSLLKL AVFALGACVA FSNANAAEGK LESIKSKGQL IVGVKNDVPH YALLDQATGE
IKGFEVDVAK LLAKSILGDD KKIKLVAVNA KTRGPLLDNG SVDAVIATFT ITPERKRIYN
FSEPYYQDAI GLLVLKEKKY KSLADMKGAN IGVAQAATTK KAIGEAAKKI GIDVKFSEFP
DYPSIKAALD AKRVDAFSVD KSILLGYVDD KSEILPDSFE PQSYGIVTKK DDPAFAKYVD
DFVKEHKNEI DALAKKWGL
