PEB2_DROME
ID PEB2_DROME Reviewed; 66 AA.
AC Q23982; Q4V3M3; Q4V3M4;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Ejaculatory bulb-specific protein 2;
DE AltName: Full=Ejaculatory bulb-specific protein II;
DE AltName: Full=PEB-meII;
DE Flags: Precursor;
GN Name=EbpII {ECO:0000312|FlyBase:FBgn0011694};
GN Synonyms=PebII {ECO:0000312|FlyBase:FBgn0011694};
GN ORFNames=CG2665 {ECO:0000312|FlyBase:FBgn0011694};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Oregon-RC; TISSUE=Ejaculatory bulb;
RX PubMed=7619487;
RA Dyanov H.M., Dzitoeva S.G.;
RT "Method for attachment of microscopic preparations on glass for in situ
RT hybridization, PRINS and in situ PCR studies.";
RL BioTechniques 18:822-824(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Protein component of the posterior mating plug.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in the ejaculatory bulb and
CC seminal fluid.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB40023.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAY55749.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U08282; AAB40023.1; ALT_INIT; mRNA.
DR EMBL; AE013599; AAF47318.2; -; Genomic_DNA.
DR EMBL; BT023332; AAY55748.1; -; mRNA.
DR EMBL; BT023333; AAY55749.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001286879.1; NM_001299950.1.
DR RefSeq; NP_523866.2; NM_079142.4.
DR AlphaFoldDB; Q23982; -.
DR BioGRID; 77362; 2.
DR DIP; DIP-20073N; -.
DR IntAct; Q23982; 2.
DR STRING; 7227.FBpp0072357; -.
DR PaxDb; Q23982; -.
DR PRIDE; Q23982; -.
DR DNASU; 326108; -.
DR EnsemblMetazoa; FBtr0072455; FBpp0072357; FBgn0011694.
DR EnsemblMetazoa; FBtr0345580; FBpp0311650; FBgn0011694.
DR GeneID; 326108; -.
DR KEGG; dme:Dmel_CG2665; -.
DR CTD; 326108; -.
DR FlyBase; FBgn0011694; EbpII.
DR VEuPathDB; VectorBase:FBgn0011694; -.
DR HOGENOM; CLU_2833892_0_0_1; -.
DR OMA; IRILVLM; -.
DR PhylomeDB; Q23982; -.
DR BioGRID-ORCS; 326108; 0 hits in 1 CRISPR screen.
DR ChiTaRS; EbpII; fly.
DR GenomeRNAi; 326108; -.
DR PRO; PR:Q23982; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0011694; Expressed in male reproductive gland and 12 other tissues.
DR ExpressionAtlas; Q23982; baseline and differential.
DR Genevisible; Q23982; DM.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:FlyBase.
DR GO; GO:0042628; P:mating plug formation; ISS:UniProtKB.
DR GO; GO:0045434; P:negative regulation of female receptivity, post-mating; IMP:FlyBase.
DR GO; GO:0019953; P:sexual reproduction; HEP:FlyBase.
PE 2: Evidence at transcript level;
KW Behavior; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..66
FT /note="Ejaculatory bulb-specific protein 2"
FT /id="PRO_0000022036"
SQ SEQUENCE 66 AA; 7187 MW; 5876561F209F3607 CRC64;
MIRILVLMIT FTLMTGSALC SIEQLMRVFG GGSVGGGSRL DINRRVTIVP PEGELSFGYG
FRPGFY
