PEBB_CAEEL
ID PEBB_CAEEL Reviewed; 152 AA.
AC Q95ZL9;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Core-binding factor subunit beta homolog bro-1 {ECO:0000305};
DE AltName: Full=BROther (Drosophila tx factor partner) homolog {ECO:0000312|WormBase:F56A3.5};
GN Name=bro-1 {ECO:0000312|WormBase:F56A3.5};
GN ORFNames=F56A3.5 {ECO:0000312|WormBase:F56A3.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, INTERACTION WITH RNT-1, SUBCELLULAR LOCATION, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=17933794; DOI=10.1242/dev.008276;
RA Kagoshima H., Nimmo R., Saad N., Tanaka J., Miwa Y., Mitani S., Kohara Y.,
RA Woollard A.;
RT "The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor,
RT RNT-1, to promote stem cell proliferation and self-renewal.";
RL Development 134:3905-3915(2007).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=18158917; DOI=10.1016/j.bbrc.2007.12.097;
RA Shim J., Lee J.;
RT "Regulation of rnt-1 expression mediated by the opposing effects of BRO-1
RT and DBL-1 in the nematode Caenorhabditis elegans.";
RL Biochem. Biophys. Res. Commun. 367:130-136(2008).
CC -!- FUNCTION: Transcriptional cofactor (PubMed:17933794). Required for
CC controlling cell proliferation in the seam cells, a stem cell-like
CC lineage, acting in concert with Runt-related transcription factor 1
CC rnt-1, perhaps by repressing expression of cyclin-dependent kinase
CC inhibitor cki-1 (PubMed:17933794). Represses expression of rnt-1
CC (PubMed:18158917). Regulates male tail development (PubMed:17933794).
CC May play a role in vulval and/or uterine morphogenesis
CC (PubMed:17933794). {ECO:0000269|PubMed:17933794,
CC ECO:0000269|PubMed:18158917}.
CC -!- SUBUNIT: Interacts with rnt-1; acts to increase the affinity and
CC specificity of interaction of rnt-1 with DNA.
CC {ECO:0000269|PubMed:17933794}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17933794}. Nucleus
CC {ECO:0000269|PubMed:17933794}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development from the late
CC embryonic stage (PubMed:18158917). Expressed in all larval stages, in
CC H0-2, V1-6, and T seam progeny, and in the uterine seam cells (utse)
CC during late larval stage L4 in hermaphrodites (PubMed:17933794).
CC Expressed in some body wall muscle cells and some pharyngeal neurons
CC (PubMed:17933794). {ECO:0000269|PubMed:17933794,
CC ECO:0000269|PubMed:18158917}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown increases expression of
CC Runt-related transcription factor rnt-1. {ECO:0000269|PubMed:18158917}.
CC -!- SIMILARITY: Belongs to the CBF-beta family. {ECO:0000305}.
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DR EMBL; BX284601; CCD66433.1; -; Genomic_DNA.
DR RefSeq; NP_491542.1; NM_059141.3.
DR AlphaFoldDB; Q95ZL9; -.
DR SMR; Q95ZL9; -.
DR STRING; 6239.F56A3.5; -.
DR EPD; Q95ZL9; -.
DR PaxDb; Q95ZL9; -.
DR EnsemblMetazoa; F56A3.5.1; F56A3.5.1; WBGene00000272.
DR GeneID; 172158; -.
DR KEGG; cel:CELE_F56A3.5; -.
DR UCSC; F56A3.5; c. elegans.
DR CTD; 172158; -.
DR WormBase; F56A3.5; CE28461; WBGene00000272; bro-1.
DR eggNOG; KOG4785; Eukaryota.
DR GeneTree; ENSGT00390000018132; -.
DR HOGENOM; CLU_1697071_0_0_1; -.
DR InParanoid; Q95ZL9; -.
DR OMA; NEINFRS; -.
DR OrthoDB; 1549677at2759; -.
DR Reactome; R-CEL-8877330; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs).
DR Reactome; R-CEL-8878166; Transcriptional regulation by RUNX2.
DR Reactome; R-CEL-8934593; Regulation of RUNX1 Expression and Activity.
DR Reactome; R-CEL-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR Reactome; R-CEL-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-CEL-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR Reactome; R-CEL-8939245; RUNX1 regulates transcription of genes involved in BCR signaling.
DR Reactome; R-CEL-8939246; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells.
DR Reactome; R-CEL-8939247; RUNX1 regulates transcription of genes involved in interleukin signaling.
DR Reactome; R-CEL-8941326; RUNX2 regulates bone development.
DR Reactome; R-CEL-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-CEL-8951936; RUNX3 regulates p14-ARF.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000272; Expressed in embryo and 3 other tissues.
DR GO; GO:0016513; C:core-binding factor complex; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
DR GO; GO:0090326; P:positive regulation of locomotion involved in locomotory behavior; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0019827; P:stem cell population maintenance; IMP:WormBase.
DR Gene3D; 2.40.250.10; -; 1.
DR InterPro; IPR003417; CBF_beta.
DR InterPro; IPR036552; CBF_bsu_sf.
DR PANTHER; PTHR10276; PTHR10276; 1.
DR Pfam; PF02312; CBF_beta; 1.
DR SUPFAM; SSF50723; SSF50723; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..152
FT /note="Core-binding factor subunit beta homolog bro-1"
FT /id="PRO_0000453626"
SQ SEQUENCE 152 AA; 17827 MW; 08A32A832E0169A5 CRC64;
MKRTTTDQQS SFQTDYFLTQ LSHFTEAKFS LFEHAPLSER RERFRVHVER DEMPLTFCKT
GINIPVKLEW SQTNGNEISF RSRPLVFNGI WVKVIGAMNS ESLEGRVRFE RFQREKRDRV
ISETFVFPEV EEEPIGLTDA EIAALRRDGL PI
