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PEBP4_MOUSE
ID   PEBP4_MOUSE             Reviewed;         242 AA.
AC   Q9D9G2; G3X8V3;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-JUN-2021, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Phosphatidylethanolamine-binding protein 4;
DE            Short=PEBP-4;
DE   Flags: Precursor;
GN   Name=Pebp4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   GLYCOSYLATION AT ASN-77 AND ASN-139.
RX   PubMed=27033522; DOI=10.1016/j.bbamcr.2016.03.022;
RA   He H., Liu D., Lin H., Jiang S., Ying Y., Chun S., Deng H., Zaia J.,
RA   Wen R., Luo Z.;
RT   "Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein
RT   and has multiple functions.";
RL   Biochim. Biophys. Acta 1863:1682-1689(2016).
CC   -!- FUNCTION: Promotes AKT phosphorylation, suggesting a possible role in
CC       the PI3K-AKT signaling pathway. {ECO:0000250|UniProtKB:Q96S96}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q96S96}.
CC   -!- SIMILARITY: Belongs to the phosphatidylethanolamine-binding protein
CC       family. {ECO:0000305}.
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DR   EMBL; AK006964; BAB24810.1; -; mRNA.
DR   EMBL; AC125151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC123867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS27245.1; -.
DR   RefSeq; NP_082836.2; NM_028560.4.
DR   AlphaFoldDB; Q9D9G2; -.
DR   SMR; Q9D9G2; -.
DR   STRING; 10090.ENSMUSP00000022678; -.
DR   GlyGen; Q9D9G2; 2 sites.
DR   PaxDb; Q9D9G2; -.
DR   PRIDE; Q9D9G2; -.
DR   ProteomicsDB; 287912; -.
DR   ProteomicsDB; 339395; -.
DR   Antibodypedia; 5316; 132 antibodies from 24 providers.
DR   DNASU; 73523; -.
DR   Ensembl; ENSMUST00000022678; ENSMUSP00000022678; ENSMUSG00000022085.
DR   GeneID; 73523; -.
DR   KEGG; mmu:73523; -.
DR   CTD; 157310; -.
DR   MGI; MGI:1920773; Pebp4.
DR   VEuPathDB; HostDB:ENSMUSG00000022085; -.
DR   eggNOG; KOG3346; Eukaryota.
DR   GeneTree; ENSGT00940000162387; -.
DR   HOGENOM; CLU_089676_0_0_1; -.
DR   InParanoid; Q9D9G2; -.
DR   OMA; QKITSWM; -.
DR   OrthoDB; 1557122at2759; -.
DR   PhylomeDB; Q9D9G2; -.
DR   TreeFam; TF315074; -.
DR   BioGRID-ORCS; 73523; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Pebp4; mouse.
DR   PRO; PR:Q9D9G2; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q9D9G2; protein.
DR   Bgee; ENSMUSG00000022085; Expressed in spermatocyte and 43 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   CDD; cd00866; PEBP_euk; 1.
DR   Gene3D; 3.90.280.10; -; 1.
DR   InterPro; IPR008914; PEBP.
DR   InterPro; IPR036610; PEBP-like_sf.
DR   InterPro; IPR035810; PEBP_euk.
DR   InterPro; IPR001858; Phosphatidylethanolamine-bd_CS.
DR   PANTHER; PTHR11362; PTHR11362; 1.
DR   Pfam; PF01161; PBP; 1.
DR   SUPFAM; SSF49777; SSF49777; 1.
DR   PROSITE; PS01220; PBP; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..242
FT                   /note="Phosphatidylethanolamine-binding protein 4"
FT                   /id="PRO_0000023280"
FT   REGION          31..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..242
FT                   /note="Important for secretion"
FT                   /evidence="ECO:0000250|UniProtKB:Q96S96"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:27033522"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:27033522"
FT   CONFLICT        13
FT                   /note="S -> R (in Ref. 1; BAB24810)"
FT   CONFLICT        94
FT                   /note="T -> P (in Ref. 1; BAB24810)"
FT   CONFLICT        169
FT                   /note="L -> V (in Ref. 1; BAB24810)"
FT   CONFLICT        193
FT                   /note="D -> N (in Ref. 1; BAB24810)"
SQ   SEQUENCE   242 AA;  26858 MW;  FF550F1BF86D3F97 CRC64;
     MTMKLVAAAL CLSLLAAGLW VGLSLTAESI EEGKPGGEKP GGGKPGGSGR GCFLPPLPKE
     DVSLCRNLEV FYMEMGNISC KIVPKCNLYR QKITAWQAPI VKFHTALDGA LYLLVMVDPD
     APSRSNPVMK YWRHWLVSNI TGADMKSGSI RGNVLSDYSP PTPPPETGLH RYQFFVYLQG
     DRDISLSVEE KADLGGWNLD KFLQQYGLRD PDTSTQFMTQ FDEELSSEFG RINDDQEQFN
     QK
 
 
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