ID   PECTR_LACP7             Reviewed;         333 AA.
AC   A9KNI6;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=HTH-type transcriptional regulator Cphy_2742;
GN   OrderedLocusNames=Cphy_2742 {ECO:0000312|EMBL:ABX43103.1};
OS   Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
OS   (Clostridium phytofermentans).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=357809;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700394 / DSM 18823 / ISDg;
RA   Leschine S.B., Warnick T.A., Blanchard J.L., Schnell D.J., Petit E.L.,
RA   LaTouf W.G., Copeland A., Lucas S., Lapidus A., Barry K.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T.,
RA   Bruce D., Detter J.C., Han C., Kuske C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E.A., Richardson P.;
RT   "Complete genome sequence of Clostridium phytofermentans ISDg.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 700394 / DSM 18823 / ISDg;
RX   PubMed=27982035; DOI=10.1038/ncomms13783;
RA   Boutard M., Ettwiller L., Cerisy T., Alberti A., Labadie K., Salanoubat M.,
RA   Schildkraut I., Tolonen A.C.;
RT   "Global repositioning of transcription start sites in a plant-fermenting
RT   bacterium.";
RL   Nat. Commun. 7:13783-13783(2016).
CC   -!- FUNCTION: Involved in control of pectin and galacturonic acid
CC       metabolism. Probably represses a comprehensive set of pectin
CC       fermentation genes by binding a conserved palindrome at or downstream
CC       of their transcription start site to block transcription. In the
CC       presence of galacturonic acid may activate transcription of acetate
CC       synthesis and other aspects of carbon metabolism.
CC       {ECO:0000269|PubMed:27982035}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated on galacturonic acid.
CC       {ECO:0000269|PubMed:27982035}.
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DR   EMBL; CP000885; ABX43103.1; -; Genomic_DNA.
DR   RefSeq; WP_012200754.1; NC_010001.1.
DR   AlphaFoldDB; A9KNI6; -.
DR   SMR; A9KNI6; -.
DR   STRING; 357809.Cphy_2742; -.
DR   EnsemblBacteria; ABX43103; ABX43103; Cphy_2742.
DR   KEGG; cpy:Cphy_2742; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_0_9; -.
DR   OMA; KTIGIMC; -.
DR   OrthoDB; 1796334at2; -.
DR   Proteomes; UP000000370; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..333
FT                   /note="HTH-type transcriptional regulator Cphy_2742"
FT                   /id="PRO_0000446250"
FT   DOMAIN          1..55
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        3..22
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   333 AA;  36876 MW;  987F2587040A6BC3 CRC64;
     MNIYDVSQKA GVSIATVSRV INGNPNVSEK TKQKVLDVMK EIGYTPNVFA RGLGLNTMKT
     IGIMCSDSSD TFLANAVYHL EQNLRKNGYD SFLCCTGYEL HTKQKYLKLL LSKRVDAIVM
     VGSSFLEANK KDNAYIMEAA DEVPIMLING YLSHPRIYCT LCDDHQAVYD AVSKLITQGR
     KEILYLYNSK SYSGLQKLSG YKAALAAHEL PLDENLMQMC PNNLADTKNL LNSLVKQGLN
     YDAVVTAEDL LAIGTIKFIK DSGRQIPQDV SIIGYNNSLL TTCCDPELTS IDNHVETLCI
     STISTLMRVL NGNDVPNKTT ISNDLIVRKT TNF