PED1B_HUMAN
ID PED1B_HUMAN Reviewed; 432 AA.
AC Q96HM7; Q96B20;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=PC-esterase domain-containing protein 1B {ECO:0000305};
DE AltName: Full=Protein FAM113B;
GN Name=PCED1B {ECO:0000312|HGNC:HGNC:28255}; Synonyms=FAM113B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96HM7; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-1222622, EBI-945833;
CC -!- SIMILARITY: Belongs to the PC-esterase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16154.1; Type=Miscellaneous discrepancy; Note=Non-canonical splice intron-exon junction.; Evidence={ECO:0000305};
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DR EMBL; CH471111; EAW57925.1; -; Genomic_DNA.
DR EMBL; BC008360; AAH08360.1; -; mRNA.
DR EMBL; BC016154; AAH16154.1; ALT_SEQ; mRNA.
DR CCDS; CCDS8752.1; -.
DR RefSeq; NP_001268358.1; NM_001281429.1.
DR RefSeq; NP_612380.1; NM_138371.2.
DR RefSeq; XP_005269281.1; XM_005269224.4.
DR RefSeq; XP_011537280.1; XM_011538978.2.
DR RefSeq; XP_016875696.1; XM_017020207.1.
DR RefSeq; XP_016875697.1; XM_017020208.1.
DR RefSeq; XP_016875698.1; XM_017020209.1.
DR RefSeq; XP_016875699.1; XM_017020210.1.
DR RefSeq; XP_016875700.1; XM_017020211.1.
DR RefSeq; XP_016875701.1; XM_017020212.1.
DR RefSeq; XP_016875702.1; XM_017020213.1.
DR RefSeq; XP_016875703.1; XM_017020214.1.
DR RefSeq; XP_016875704.1; XM_017020215.1.
DR RefSeq; XP_016875705.1; XM_017020216.1.
DR AlphaFoldDB; Q96HM7; -.
DR BioGRID; 124840; 9.
DR IntAct; Q96HM7; 5.
DR STRING; 9606.ENSP00000446688; -.
DR PhosphoSitePlus; Q96HM7; -.
DR BioMuta; PCED1B; -.
DR DMDM; 74731954; -.
DR jPOST; Q96HM7; -.
DR MassIVE; Q96HM7; -.
DR PaxDb; Q96HM7; -.
DR PeptideAtlas; Q96HM7; -.
DR PRIDE; Q96HM7; -.
DR Antibodypedia; 49373; 24 antibodies from 12 providers.
DR DNASU; 91523; -.
DR Ensembl; ENST00000432328.2; ENSP00000396040.1; ENSG00000179715.13.
DR Ensembl; ENST00000546455.6; ENSP00000446688.1; ENSG00000179715.13.
DR GeneID; 91523; -.
DR KEGG; hsa:91523; -.
DR MANE-Select; ENST00000546455.6; ENSP00000446688.1; NM_138371.3; NP_612380.1.
DR UCSC; uc001rpn.5; human.
DR CTD; 91523; -.
DR DisGeNET; 91523; -.
DR GeneCards; PCED1B; -.
DR HGNC; HGNC:28255; PCED1B.
DR HPA; ENSG00000179715; Tissue enhanced (adrenal gland, lymphoid tissue).
DR neXtProt; NX_Q96HM7; -.
DR OpenTargets; ENSG00000179715; -.
DR PharmGKB; PA143485471; -.
DR VEuPathDB; HostDB:ENSG00000179715; -.
DR eggNOG; ENOG502QVBZ; Eukaryota.
DR GeneTree; ENSGT00390000002231; -.
DR HOGENOM; CLU_053865_0_0_1; -.
DR InParanoid; Q96HM7; -.
DR OMA; RGPYVPW; -.
DR PhylomeDB; Q96HM7; -.
DR TreeFam; TF328972; -.
DR PathwayCommons; Q96HM7; -.
DR SignaLink; Q96HM7; -.
DR BioGRID-ORCS; 91523; 49 hits in 1075 CRISPR screens.
DR ChiTaRS; PCED1B; human.
DR GenomeRNAi; 91523; -.
DR Pharos; Q96HM7; Tdark.
DR PRO; PR:Q96HM7; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q96HM7; protein.
DR Bgee; ENSG00000179715; Expressed in granulocyte and 111 other tissues.
DR ExpressionAtlas; Q96HM7; baseline and differential.
DR Genevisible; Q96HM7; HS.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR036514; SGNH_hydro_sf.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..432
FT /note="PC-esterase domain-containing protein 1B"
FT /id="PRO_0000331356"
FT REGION 264..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 429
FT /note="P -> A (in dbSNP:rs2543737)"
FT /id="VAR_042761"
SQ SEQUENCE 432 AA; 49727 MW; F21497B76A791926 CRC64;
MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA RGELNFEQDE
LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD YLQTILKELQ SGEHAPDLVI
MNSCLWDISR YGPNSWRSYL ENLENLFQCL GQVLPESCLL VWNTAMPVGE EVTGGFLPPK
LRRQKATFLK NEVVKANFHS ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL
SQLLLAHVAD AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR
PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS DQFYCHSDVP
SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF GRYRPRGPYT PWGQRPRPSK
RRAPANPEPR PQ