PELI_DROME
ID PELI_DROME Reviewed; 424 AA.
AC O77237;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Protein pellino;
GN Name=Pli; ORFNames=CG5212;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND INTERACTION WITH PLL.
RX PubMed=10330490; DOI=10.1016/s0925-4773(98)00236-6;
RA Grosshans J., Schnorrer F., Nuesslein-Volhard C.;
RT "Oligomerisation of Tube and Pelle leads to nuclear localisation of
RT dorsal.";
RL Mech. Dev. 81:127-138(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Scaffold protein involved in the Toll signaling pathway via
CC its interaction with pelle/pll kinase.
CC -!- SUBUNIT: Interacts with pll. {ECO:0000269|PubMed:10330490}.
CC -!- INTERACTION:
CC O77237; Q9VWL9: RhoGAP18B; NbExp=3; IntAct=EBI-92779, EBI-105009;
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically with low
CC levels of expression throughout the life cycle.
CC {ECO:0000269|PubMed:10330490}.
CC -!- SIMILARITY: Belongs to the pellino family. {ECO:0000305}.
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DR EMBL; AF091624; AAC96298.1; -; mRNA.
DR EMBL; AE014297; AAF56198.1; -; Genomic_DNA.
DR EMBL; AY069632; AAL39777.1; -; mRNA.
DR RefSeq; NP_001097890.1; NM_001104420.3.
DR RefSeq; NP_524466.1; NM_079742.4.
DR AlphaFoldDB; O77237; -.
DR SMR; O77237; -.
DR BioGRID; 67757; 29.
DR IntAct; O77237; 13.
DR STRING; 7227.FBpp0111820; -.
DR iPTMnet; O77237; -.
DR PaxDb; O77237; -.
DR PRIDE; O77237; -.
DR DNASU; 42821; -.
DR EnsemblMetazoa; FBtr0084527; FBpp0083913; FBgn0025574.
DR EnsemblMetazoa; FBtr0112907; FBpp0111820; FBgn0025574.
DR GeneID; 42821; -.
DR KEGG; dme:Dmel_CG5212; -.
DR CTD; 42821; -.
DR FlyBase; FBgn0025574; Pli.
DR VEuPathDB; VectorBase:FBgn0025574; -.
DR eggNOG; KOG3842; Eukaryota.
DR GeneTree; ENSGT00950000183050; -.
DR HOGENOM; CLU_029221_2_0_1; -.
DR InParanoid; O77237; -.
DR OMA; IMHPRGQ; -.
DR OrthoDB; 837213at2759; -.
DR PhylomeDB; O77237; -.
DR Reactome; R-DME-9020702; Interleukin-1 signaling.
DR BioGRID-ORCS; 42821; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42821; -.
DR PRO; PR:O77237; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0025574; Expressed in saliva-secreting gland and 22 other tissues.
DR ExpressionAtlas; O77237; baseline and differential.
DR Genevisible; O77237; DM.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:FlyBase.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0019207; F:kinase regulator activity; IMP:UniProtKB.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IMP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IMP:FlyBase.
DR GO; GO:1905035; P:negative regulation of antifungal innate immune response; IMP:FlyBase.
DR GO; GO:1900425; P:negative regulation of defense response to bacterium; IMP:FlyBase.
DR GO; GO:0045751; P:negative regulation of Toll signaling pathway; IMP:FlyBase.
DR GO; GO:0002225; P:positive regulation of antimicrobial peptide production; IMP:FlyBase.
DR GO; GO:0045752; P:positive regulation of Toll signaling pathway; IMP:FlyBase.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IMP:FlyBase.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0008063; P:Toll signaling pathway; IMP:UniProtKB.
DR InterPro; IPR006800; Pellino_fam.
DR PANTHER; PTHR12098; PTHR12098; 1.
DR Pfam; PF04710; Pellino; 1.
DR PIRSF; PIRSF038886; Pellino; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..424
FT /note="Protein pellino"
FT /id="PRO_0000194178"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 424 AA; 46770 MW; B6A99CB1C72C5F40 CRC64;
MVKRTDGTES PILAEDGGDG HDKPRLRYGE LVILGYNGYL PQGDRGRRRS KFVLHKRTEA
SGVKRSKHYI VQSPQTSKAI LDANQHSISY TLSRNQAVIV EYKEDTETDM FQVGRSSESP
IDFVVMDTLP GDKKDAKVMQ STISRFACRI LVNRCEPAKA RIFAAGFDSS RNIFLGEKAT
KWQDNVEIDG LTTNGVLIMH PKGSFCGGNA KCGLWRECSV GGDVFSLRES RSAQQKGQPI
YDECNILQDG TLIDLCGATL LWRSAEGLQH SPTKHDLEKL IDAINAGRPQ CPVGLNTLVI
PRKVNIGDQV NQPYVYLNCG HVQGHHDWGQ DENTGARRCP MCLELGPVVT LCMGLEPAFY
VDVGAPTYAF NPCGHMATEK TVKYWANVEI PHGTNGFQAV CPFCATPLDG ATGYIKLIFQ
DNLD
