ID   PEM_IRPLA               Reviewed;          35 AA.
AC   P83918;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Manganese peroxidase;
DE            EC=1.11.1.13;
DE   AltName: Full=Peroxidase manganese-dependent;
DE   Flags: Fragments;
OS   Irpex lacteus (Milk-white toothed polypore) (Polyporus tulipiferae).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Irpicaceae; Irpex.
OX   NCBI_TaxID=5319;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND INDUCTION.
RX   PubMed=16410766;
RA   Shin K.-S., Kim Y.H., Lim J.-S.;
RT   "Purification and characterization of manganese peroxidase of the white-rot
RT   fungus Irpex lacteus.";
RL   J. Microbiol. 43:503-509(2005).
CC   -!- FUNCTION: Has manganese peroxidase activity.
CC       {ECO:0000269|PubMed:16410766, ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+);
CC         Xref=Rhea:RHEA:22776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:29035, ChEBI:CHEBI:29041;
CC         EC=1.11.1.13; Evidence={ECO:0000305};
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00297};
CC       Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
CC       {ECO:0000255|PROSITE-ProRule:PRU00297};
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00297};
CC       Note=Binds 2 calcium ions per subunit. {ECO:0000255|PROSITE-
CC       ProRule:PRU00297};
CC   -!- INDUCTION: By incubation with textile industry wastewater.
CC       {ECO:0000269|PubMed:16410766, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peroxidase family. {ECO:0000305}.
CC   -!- CAUTION: The order of the peptides shown is unknown. {ECO:0000305}.
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DR   AlphaFoldDB; P83918; -.
DR   GO; GO:0016689; F:manganese peroxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Hydrogen peroxide; Iron; Manganese;
KW   Metal-binding; Oxidoreductase; Peroxidase.
FT   CHAIN           <1..>35
FT                   /note="Manganese peroxidase"
FT                   /id="PRO_0000055615"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_CONS        9..10
FT                   /evidence="ECO:0000305"
FT   NON_CONS        24..25
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
FT   NON_TER         35
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   35 AA;  3819 MW;  A50241B69A6A805D CRC64;
     LSLLGHDERV TPEPFDSVTA QNARGNQADV QSLPR