ID   PEN1_PENVA              Reviewed;          50 AA.
AC   P81056;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Penaeidin-1;
DE            Short=P1;
DE            Short=Pen-1;
OS   Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=6689;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Hemocyte;
RX   PubMed=9353298; DOI=10.1074/jbc.272.45.28398;
RA   Destoumieux D., Bulet P., Loew D., van Dorsselaer A., Rodriguez J.,
RA   Bachere E.;
RT   "Penaeidins, a new family of antimicrobial peptides isolated from the
RT   shrimp Penaeus vannamei (Decapoda).";
RL   J. Biol. Chem. 272:28398-28406(1997).
RN   [2]
RP   CHITIN-BINDING PROPERTIES, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Hemocyte;
RX   PubMed=10639333; DOI=10.1242/jcs.113.3.461;
RA   Destoumieux D., Munoz M., Cosseau C., Rodriguez J., Bulet P., Comps M.,
RA   Bachere E.;
RT   "Penaeidins, antimicrobial peptides with chitin-binding activity, are
RT   produced and stored in shrimp granulocytes and released after microbial
RT   challenge.";
RL   J. Cell Sci. 113:461-469(2000).
RN   [3]
RP   REVIEW.
RX   PubMed=11028917; DOI=10.1007/pl00000764;
RA   Destoumieux D., Munoz M., Bulet P., Bachere E.;
RT   "Penaeidins, a family of antimicrobial peptides from penaeid shrimp
RT   (Crustacea, Decapoda).";
RL   Cell. Mol. Life Sci. 57:1260-1271(2000).
CC   -!- FUNCTION: Antibacterial activity against M.luteus and E.coli bacteria.
CC       Antifungal activity against N.crassa and F.oxysporum. Presents chitin-
CC       binding activity. {ECO:0000269|PubMed:9353298}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule
CC       {ECO:0000269|PubMed:10639333}. Note=Cytoplasmic granules of hemocytes
CC       and to a lesser extent in small granules of hemocytes.
CC   -!- TISSUE SPECIFICITY: Higher expression in hemocytes and to a lesser
CC       extent in heart, testis, gills, intestine, lymphoid organ and
CC       hepatopancreas. Traces in eyes and subcuticular epithelium. Not present
CC       in the brain. {ECO:0000269|PubMed:10639333}.
CC   -!- DEVELOPMENTAL STAGE: Expression decreases 3 hours after microbial
CC       challenge to return to control levels after 12 hours and slightly
CC       increases after 24 hours. {ECO:0000269|PubMed:10639333}.
CC   -!- MASS SPECTROMETRY: Mass=5484.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:9353298};
CC   -!- SIMILARITY: Belongs to the penaeidin family. {ECO:0000305}.
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DR   AlphaFoldDB; P81056; -.
DR   SMR; P81056; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR009226; Penaeidin.
DR   Pfam; PF05927; Penaeidin; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Chitin-binding; Direct protein sequencing;
KW   Disulfide bond; Fungicide.
FT   CHAIN           1..50
FT                   /note="Penaeidin-1"
FT                   /id="PRO_0000215909"
FT   DISULFID        25..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        27..45
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..46
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   50 AA;  5492 MW;  61FDB180C31ADBE5 CRC64;
     YRGGYTGPIP RPPPIGRPPL RLVVCACYRL SVSDARNCCI KFGSCCHLVK