PEN2D_PENST
ID PEN2D_PENST Reviewed; 72 AA.
AC Q962A9;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Penaeidin-2d;
DE Short=Pen-2d;
DE Flags: Precursor;
OS Penaeus setiferus (Atlantic white shrimp) (Litopenaeus setiferus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=64468;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hemocyte;
RX PubMed=12242595; DOI=10.1007/s00251-002-0487-z;
RA Cuthbertson B.J., Shepard E.F., Chapman R.W., Gross P.S.;
RT "Diversity of the penaeidin antimicrobial peptides in two shrimp species.";
RL Immunogenetics 54:442-445(2002).
CC -!- FUNCTION: Antibacterial and antifungal activity. Presents chitin-
CC binding activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of
CC hemocytes and to a lesser extent in small granules of hemocytes.
CC -!- SIMILARITY: Belongs to the penaeidin family. {ECO:0000305}.
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DR EMBL; AY039205; AAK83453.1; -; mRNA.
DR AlphaFoldDB; Q962A9; -.
DR SMR; Q962A9; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR009226; Penaeidin.
DR Pfam; PF05927; Penaeidin; 1.
PE 3: Inferred from homology;
KW Amidation; Antibiotic; Antimicrobial; Chitin-binding; Disulfide bond;
KW Fungicide; Pyrrolidone carboxylic acid; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..71
FT /note="Penaeidin-2d"
FT /id="PRO_0000023505"
FT MOD_RES 22
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 71
FT /note="Lysine amide"
FT /evidence="ECO:0000250"
FT DISULFID 45..59
FT /evidence="ECO:0000250"
FT DISULFID 48..66
FT /evidence="ECO:0000250"
FT DISULFID 60..67
FT /evidence="ECO:0000250"
SQ SEQUENCE 72 AA; 7717 MW; 7DCE24C8F3D3F182 CRC64;
MRLVVCLVFL ASFALVCQGG AQRGGFTGPI PRPPPHGRPP LGPICNACYR LSFSDVRICC
NFLGKCCHLV KG