PEN2_CAEEL
ID PEN2_CAEEL Reviewed; 101 AA.
AC Q9U357;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Gamma-secretase subunit pen-2;
DE AltName: Full=Presenilin enhancer protein 2;
GN Name=pen-2; ORFNames=T28D6.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=12110170; DOI=10.1016/s1534-5807(02)00189-2;
RA Francis R., McGrath G., Zhang J., Ruddy D.A., Sym M., Apfeld J., Nicoll M.,
RA Maxwell M., Hai B., Ellis M.C., Parks A.L., Xu W., Li J., Gurney M.,
RA Myers R.L., Himes C.S., Hiebsch R., Ruble C., Nye J.S., Curtis D.;
RT "aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase
RT cleavage of betaAPP, and presenilin protein accumulation.";
RL Dev. Cell 3:85-97(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Essential subunit of the gamma-secretase complex, an
CC endoprotease complex that catalyzes the intramembrane cleavage of
CC integral membrane proteins such as Notch (glp-1 or lin-12). It may
CC represent a stabilizing cofactor for the presenilin homodimer that
CC promotes the formation of a stable complex.
CC {ECO:0000269|PubMed:12110170}.
CC -!- SUBUNIT: Component of the gamma-secretase complex, a complex probably
CC composed of the presenilin homodimer (sel-12, hop-1 or spe-4),
CC nicastrin (aph-2), aph-1 and pen-2. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:12110170}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12110170}. Golgi apparatus membrane
CC {ECO:0000269|PubMed:12110170}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12110170}. Note=Predominantly located in the
CC endoplasmic reticulum and Golgi region.
CC -!- TISSUE SPECIFICITY: Expressed from 100-cell stage in most somatic
CC tissues, including neurons, muscle, intestine and developing vulva.
CC Little or not expressed in early embryos.
CC {ECO:0000269|PubMed:12110170}.
CC -!- SIMILARITY: Belongs to the PEN-2 family. {ECO:0000305}.
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DR EMBL; Z81134; CAB54316.1; -; Genomic_DNA.
DR PIR; T25417; T25417.
DR RefSeq; NP_499459.1; NM_067058.4.
DR AlphaFoldDB; Q9U357; -.
DR SMR; Q9U357; -.
DR BioGRID; 41747; 2.
DR DIP; DIP-26665N; -.
DR STRING; 6239.T28D6.9; -.
DR PaxDb; Q9U357; -.
DR EnsemblMetazoa; T28D6.9.1; T28D6.9.1; WBGene00003975.
DR GeneID; 176565; -.
DR KEGG; cel:CELE_T28D6.9; -.
DR UCSC; T28D6.9; c. elegans.
DR CTD; 251430; -.
DR WormBase; T28D6.9; CE24023; WBGene00003975; pen-2.
DR eggNOG; KOG3402; Eukaryota.
DR GeneTree; ENSGT00390000016319; -.
DR HOGENOM; CLU_124142_2_0_1; -.
DR InParanoid; Q9U357; -.
DR OMA; WYFRAGF; -.
DR OrthoDB; 1517974at2759; -.
DR PhylomeDB; Q9U357; -.
DR Reactome; R-CEL-1251985; Nuclear signaling by ERBB4.
DR SignaLink; Q9U357; -.
DR PRO; PR:Q9U357; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003975; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070765; C:gamma-secretase complex; ISS:WormBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:WormBase.
DR GO; GO:0045165; P:cell fate commitment; IGI:WormBase.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0048598; P:embryonic morphogenesis; IMP:WormBase.
DR GO; GO:0007281; P:germ cell development; IGI:WormBase.
DR GO; GO:0007220; P:Notch receptor processing; IBA:GO_Central.
DR GO; GO:0007219; P:Notch signaling pathway; IMP:WormBase.
DR GO; GO:0060465; P:pharynx development; IMP:WormBase.
DR InterPro; IPR019379; Gamma_Secretase_Asp_P_PEN2.
DR PANTHER; PTHR16318; PTHR16318; 1.
DR Pfam; PF10251; PEN-2; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Notch signaling pathway;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..101
FT /note="Gamma-secretase subunit pen-2"
FT /id="PRO_0000190903"
FT TOPO_DOM 1..17
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..101
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 101 AA; 11943 MW; 4DE2725C569CDB4B CRC64;
MDISKLTDVK KVDLCKKYFL IGACFLPLVW IVNTFWFFSD AFCKPINAHR RQIRKYVIAS
IVGSIFWIIV LSAWEIFFQH YRAQGLVWTD FLTFVFPTGR V
