PEN3C_PENVA
ID PEN3C_PENVA Reviewed; 81 AA.
AC P81060;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Penaeidin-3c;
DE Short=P3-c;
DE Short=Pen-3c;
DE Flags: Precursor;
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hemocyte;
RX PubMed=9353298; DOI=10.1074/jbc.272.45.28398;
RA Destoumieux D., Bulet P., Loew D., van Dorsselaer A., Rodriguez J.,
RA Bachere E.;
RT "Penaeidins, a new family of antimicrobial peptides isolated from the
RT shrimp Penaeus vannamei (Decapoda).";
RL J. Biol. Chem. 272:28398-28406(1997).
RN [2]
RP CHITIN-BINDING PROPERTIES, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Hemocyte;
RX PubMed=10639333; DOI=10.1242/jcs.113.3.461;
RA Destoumieux D., Munoz M., Cosseau C., Rodriguez J., Bulet P., Comps M.,
RA Bachere E.;
RT "Penaeidins, antimicrobial peptides with chitin-binding activity, are
RT produced and stored in shrimp granulocytes and released after microbial
RT challenge.";
RL J. Cell Sci. 113:461-469(2000).
RN [3]
RP REVIEW.
RX PubMed=11028917; DOI=10.1007/pl00000764;
RA Destoumieux D., Munoz M., Bulet P., Bachere E.;
RT "Penaeidins, a family of antimicrobial peptides from penaeid shrimp
RT (Crustacea, Decapoda).";
RL Cell. Mol. Life Sci. 57:1260-1271(2000).
CC -!- FUNCTION: Antibacterial activity against M.luteus and E.coli bacteria.
CC Antifungal activity against N.crassa and F.oxysporum. Presents chitin-
CC binding activity.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule
CC {ECO:0000269|PubMed:10639333}. Note=Cytoplasmic granules of hemocytes
CC and to a lesser extent in small granules of hemocytes.
CC -!- TISSUE SPECIFICITY: Higher expression in hemocytes and to a lesser
CC extent in heart, testis, gills, intestine, lymphoid organ and
CC hepatopancreas. Traces in eyes and subcuticular epithelium. Not present
CC in the brain. {ECO:0000269|PubMed:10639333}.
CC -!- DEVELOPMENTAL STAGE: Expression decreases 3 hours after microbial
CC challenge to return to control levels after 12 hours and slightly
CC increases after 24 hours. {ECO:0000269|PubMed:10639333}.
CC -!- SIMILARITY: Belongs to the penaeidin family. {ECO:0000305}.
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DR EMBL; Y14928; CAA75145.1; -; mRNA.
DR AlphaFoldDB; P81060; -.
DR SMR; P81060; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR009226; Penaeidin.
DR Pfam; PF05927; Penaeidin; 1.
PE 1: Evidence at protein level;
KW Amidation; Antibiotic; Antimicrobial; Chitin-binding; Disulfide bond;
KW Fungicide; Pyrrolidone carboxylic acid; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..80
FT /note="Penaeidin-3c"
FT /id="PRO_0000023508"
FT MOD_RES 20
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 80
FT /note="Serine amide"
FT /evidence="ECO:0000250"
FT DISULFID 50..65
FT /evidence="ECO:0000250"
FT DISULFID 54..72
FT /evidence="ECO:0000250"
FT DISULFID 66..73
FT /evidence="ECO:0000250"
SQ SEQUENCE 81 AA; 8637 MW; 2950B36163B92C36 CRC64;
MRLVVCLVFL ASFALVCQGQ VYKGGYTRPI PRPPFVRPVP GGPIGPYNGC PVSCRGISFS
QARSCCSRLG RCCHVGKGYS G
