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PEN4D_PENST
ID   PEN4D_PENST             Reviewed;          67 AA.
AC   Q962A7;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Penaeidin-4d;
DE            Short=Pen-4d;
DE   Flags: Precursor;
OS   Penaeus setiferus (Atlantic white shrimp) (Litopenaeus setiferus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=64468;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hemocyte;
RX   PubMed=12242595; DOI=10.1007/s00251-002-0487-z;
RA   Cuthbertson B.J., Shepard E.F., Chapman R.W., Gross P.S.;
RT   "Diversity of the penaeidin antimicrobial peptides in two shrimp species.";
RL   Immunogenetics 54:442-445(2002).
RN   [2]
RP   STRUCTURE BY NMR OF 20-66, AND DISULFIDE BONDS.
RX   PubMed=15699044; DOI=10.1074/jbc.m412420200;
RA   Cuthbertson B.J., Yang Y., Bachere E., Bullesbach E.E., Gross P.S.,
RA   Aumelas A.;
RT   "Solution structure of synthetic penaeidin-4 with structural and functional
RT   comparisons with penaeidin-3.";
RL   J. Biol. Chem. 280:16009-16018(2005).
CC   -!- FUNCTION: Antibacterial and antifungal activity. Presents chitin-
CC       binding activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of
CC       hemocytes and to a lesser extent in small granules of hemocytes.
CC   -!- SIMILARITY: Belongs to the penaeidin family. {ECO:0000305}.
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DR   EMBL; AY039207; AAK83455.1; -; mRNA.
DR   PDB; 1XV3; NMR; -; A=20-66.
DR   PDBsum; 1XV3; -.
DR   AlphaFoldDB; Q962A7; -.
DR   SMR; Q962A7; -.
DR   EvolutionaryTrace; Q962A7; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR009226; Penaeidin.
DR   Pfam; PF05927; Penaeidin; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Antibiotic; Antimicrobial; Chitin-binding;
KW   Disulfide bond; Fungicide; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..66
FT                   /note="Penaeidin-4d"
FT                   /id="PRO_0000023522"
FT   MOD_RES         66
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000269|PubMed:15699044"
FT   DISULFID        45..63
FT                   /evidence="ECO:0000269|PubMed:15699044"
FT   DISULFID        57..64
FT                   /evidence="ECO:0000269|PubMed:15699044"
FT   TURN            45..47
FT                   /evidence="ECO:0007829|PDB:1XV3"
FT   HELIX           50..58
FT                   /evidence="ECO:0007829|PDB:1XV3"
SQ   SEQUENCE   67 AA;  7445 MW;  1802FDF499F47797 CRC64;
     MRLLVCLVFL ASFAMVCQGH SSGYTRPLRK PSRPIFIRPI GCDVCYGIPS STARLCCFRY
     GDCCHLG
 
 
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