PEN4D_PENST
ID PEN4D_PENST Reviewed; 67 AA.
AC Q962A7;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Penaeidin-4d;
DE Short=Pen-4d;
DE Flags: Precursor;
OS Penaeus setiferus (Atlantic white shrimp) (Litopenaeus setiferus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=64468;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hemocyte;
RX PubMed=12242595; DOI=10.1007/s00251-002-0487-z;
RA Cuthbertson B.J., Shepard E.F., Chapman R.W., Gross P.S.;
RT "Diversity of the penaeidin antimicrobial peptides in two shrimp species.";
RL Immunogenetics 54:442-445(2002).
RN [2]
RP STRUCTURE BY NMR OF 20-66, AND DISULFIDE BONDS.
RX PubMed=15699044; DOI=10.1074/jbc.m412420200;
RA Cuthbertson B.J., Yang Y., Bachere E., Bullesbach E.E., Gross P.S.,
RA Aumelas A.;
RT "Solution structure of synthetic penaeidin-4 with structural and functional
RT comparisons with penaeidin-3.";
RL J. Biol. Chem. 280:16009-16018(2005).
CC -!- FUNCTION: Antibacterial and antifungal activity. Presents chitin-
CC binding activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of
CC hemocytes and to a lesser extent in small granules of hemocytes.
CC -!- SIMILARITY: Belongs to the penaeidin family. {ECO:0000305}.
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DR EMBL; AY039207; AAK83455.1; -; mRNA.
DR PDB; 1XV3; NMR; -; A=20-66.
DR PDBsum; 1XV3; -.
DR AlphaFoldDB; Q962A7; -.
DR SMR; Q962A7; -.
DR EvolutionaryTrace; Q962A7; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR009226; Penaeidin.
DR Pfam; PF05927; Penaeidin; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Amidation; Antibiotic; Antimicrobial; Chitin-binding;
KW Disulfide bond; Fungicide; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..66
FT /note="Penaeidin-4d"
FT /id="PRO_0000023522"
FT MOD_RES 66
FT /note="Leucine amide"
FT /evidence="ECO:0000250"
FT DISULFID 42..56
FT /evidence="ECO:0000269|PubMed:15699044"
FT DISULFID 45..63
FT /evidence="ECO:0000269|PubMed:15699044"
FT DISULFID 57..64
FT /evidence="ECO:0000269|PubMed:15699044"
FT TURN 45..47
FT /evidence="ECO:0007829|PDB:1XV3"
FT HELIX 50..58
FT /evidence="ECO:0007829|PDB:1XV3"
SQ SEQUENCE 67 AA; 7445 MW; 1802FDF499F47797 CRC64;
MRLLVCLVFL ASFAMVCQGH SSGYTRPLRK PSRPIFIRPI GCDVCYGIPS STARLCCFRY
GDCCHLG