ID   PEN7_ARATH              Reviewed;         761 AA.
AC   Q9LS68; F4J2Z9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 3.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Putative pentacyclic triterpene synthase 7;
DE            Short=AtPEN7;
DE            EC=5.4.99.-;
GN   Name=PEN7; OrderedLocusNames=At3g29255; ORFNames=MXO21.12;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   IDENTIFICATION, AND NOMENCLATURE.
RX   PubMed=11247608; DOI=10.1023/a:1006476123930;
RA   Husselstein-Muller T., Schaller H., Benveniste P.;
RT   "Molecular cloning and expression in yeast of 2,3-oxidosqualene-
RT   triterpenoid cyclases from Arabidopsis thaliana.";
RL   Plant Mol. Biol. 45:75-92(2001).
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AEE77558.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAB01823.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAB01823.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB026657; BAB01823.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE77558.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001154653.1; NM_001161181.1.
DR   AlphaFoldDB; Q9LS68; -.
DR   SMR; Q9LS68; -.
DR   STRING; 3702.AT3G29255.1; -.
DR   PeptideAtlas; Q9LS68; -.
DR   PRIDE; Q9LS68; -.
DR   GeneID; 3768995; -.
DR   KEGG; ath:AT3G29255; -.
DR   Araport; AT3G29255; -.
DR   eggNOG; KOG0497; Eukaryota.
DR   InParanoid; Q9LS68; -.
DR   OrthoDB; 365003at2759; -.
DR   BioCyc; ARA:AT3G29255-MON; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0042300; F:beta-amyrin synthase activity; IBA:GO_Central.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IBA:GO_Central.
DR   CDD; cd02892; SQCY_1; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11764; PTHR11764; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; SSF48239; 2.
DR   TIGRFAMs; TIGR01787; squalene_cyclas; 1.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   5: Uncertain;
KW   Isomerase; Reference proteome; Repeat.
FT   CHAIN           1..761
FT                   /note="Putative pentacyclic triterpene synthase 7"
FT                   /id="PRO_0000366142"
FT   REPEAT          149..190
FT                   /note="PFTB 1"
FT   REPEAT          593..633
FT                   /note="PFTB 2"
FT   REPEAT          642..683
FT                   /note="PFTB 3"
FT   ACT_SITE        487
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:P48449"
FT   CONFLICT        1
FT                   /note="M -> K (in Ref. 1; BAB01823)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   761 AA;  88288 MW;  083BD9F54CD80999 CRC64;
     MWKLRIGAKA GDDPHLCTTN NYLGRQIWEF DTNACSPEEL FEVEKARRNF SDNRSQYKAS
     ADLLWRMQFL REKKFKQNIP RVKIEDAEKI TYEEANMTLR RGIHYMAALQ SDDGHWPAEN
     SGCMFFNAPF VICLYITGHL DTIFSQEHRK EMLRYIPIIK NDDGGWGLDV ESHSSMFCTV
     LNYICLRIME VDPDHDRKKS ACARARKWII DRGGATYTPL FGKACLSVLG VYEWSGCKPI
     PPEFWLFPSY FPINGGTVWI YFRDTFMALS YLYGKKFVAT PTPLILQLRQ ELYPQTYADI
     VWSQARNRCA KEDLYYPQTF VQDLFWKSVH MFSENILNRW PFKKLIRERA IRRALELIHY
     HDEATQYITG GGVPKVFHML ACWAEGPESG YFKKHLARVS GFIWISEDGL KIQSFGSQIW
     DTVLLLKVML AADIDDEIRS MLIKGYSFLR KSQLIENPPG YYIKMFRDIS KGGWGFSDKD
     QGWPASDCTS ESLECCLIFE SMPSNFIDEK MDVERLYDAV NMLLYLQSEN GGKAVWERAS
     GKKWLEWLSP IEFMEETILE HEYVECTGSA VVVLTRFMKQ FPRHRTKEIE TFIAKAVKYI
     ESLQMADGSW YGNWGVCFIY ATFFAVRGLV AAGKTYQSYE PIRRAVQFLL KIQNDEGGWG
     ESFLSCPGKK YISLEGNKTN VVNTGQAMMV LIMSGQMERD PLPVHRAAKV LINSQMENGD
     FPQQELRGVY KMNVLLHYPT YRNIFSLWAL TYYTKALRLL L