ID   PENG_DROME              Reviewed;         737 AA.
AC   O61345; Q9VRH2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Protein penguin;
GN   Name=peng {ECO:0000312|FlyBase:FBgn0015527};
GN   Synonyms=pen {ECO:0000312|FlyBase:FBgn0015527};
GN   ORFNames=CG1685 {ECO:0000312|FlyBase:FBgn0015527};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Canton-S;
RX   PubMed=9520435; DOI=10.1073/pnas.95.7.3731;
RA   Maleszka R., de Couet H.G., Miklos G.L.G.;
RT   "Data transferability from model organisms to human beings: insights from
RT   the functional genomics of the flightless region of Drosophila.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA   Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA   Harvey D.A.;
RT   "A Drosophila complementary DNA resource.";
RL   Science 287:2222-2224(2000).
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DR   EMBL; AF017777; AAC28403.1; -; Genomic_DNA.
DR   EMBL; AE014298; AAF50828.1; -; Genomic_DNA.
DR   EMBL; AF132165; AAD34753.1; -; mRNA.
DR   PIR; T08427; T08427.
DR   RefSeq; NP_523429.1; NM_078705.3.
DR   AlphaFoldDB; O61345; -.
DR   SMR; O61345; -.
DR   BioGRID; 59390; 7.
DR   DIP; DIP-21277N; -.
DR   IntAct; O61345; 1.
DR   STRING; 7227.FBpp0076918; -.
DR   PaxDb; O61345; -.
DR   PRIDE; O61345; -.
DR   DNASU; 33112; -.
DR   EnsemblMetazoa; FBtr0077223; FBpp0076918; FBgn0015527.
DR   GeneID; 33112; -.
DR   KEGG; dme:Dmel_CG1685; -.
DR   UCSC; CG1685-RA; d. melanogaster.
DR   CTD; 33112; -.
DR   FlyBase; FBgn0015527; peng.
DR   VEuPathDB; VectorBase:FBgn0015527; -.
DR   eggNOG; KOG2050; Eukaryota.
DR   GeneTree; ENSGT00390000015757; -.
DR   HOGENOM; CLU_013994_0_0_1; -.
DR   InParanoid; O61345; -.
DR   OMA; HIQGESY; -.
DR   OrthoDB; 845051at2759; -.
DR   PhylomeDB; O61345; -.
DR   BioGRID-ORCS; 33112; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; Pen; fly.
DR   GenomeRNAi; 33112; -.
DR   PRO; PR:O61345; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0015527; Expressed in eye disc (Drosophila) and 44 other tissues.
DR   Genevisible; O61345; DM.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0007475; P:apposition of dorsal and ventral imaginal disc-derived wing surfaces; IMP:FlyBase.
DR   GO; GO:0006417; P:regulation of translation; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012959; CPL_dom.
DR   InterPro; IPR033133; PUM-HD.
DR   InterPro; IPR040059; PUM3.
DR   InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR   PANTHER; PTHR13389; PTHR13389; 1.
DR   Pfam; PF08144; CPL; 1.
DR   SMART; SM00025; Pumilio; 4.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50302; PUM; 5.
DR   PROSITE; PS50303; PUM_HD; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..737
FT                   /note="Protein penguin"
FT                   /id="PRO_0000075921"
FT   DOMAIN          139..490
FT                   /note="PUM-HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00318"
FT   REPEAT          167..202
FT                   /note="Pumilio 1"
FT   REPEAT          203..238
FT                   /note="Pumilio 2"
FT   REPEAT          239..274
FT                   /note="Pumilio 3"
FT   REPEAT          388..425
FT                   /note="Pumilio 4"
FT   REPEAT          426..462
FT                   /note="Pumilio 5"
FT   REGION          1..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          577..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..93
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..603
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        604..631
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   737 AA;  81302 MW;  C7A4E212A9ED0FDD CRC64;
     MVSSEPKGPA NVANTASPLK AHESSGKRAN GQKFKPGGAG GARKFDKFGG GAGKSFVKPG
     AGGAKKFDKS GPGGFKKFDK SGATGDKRLG GNKFRGKPQT QPQAPAEGEK QDWNKFKKEK
     KDLKLKRKSA KDTYEISKEA NQIHEKLRCR RTENKDKLVE QIYKVLNVGD TISKVVKAHD
     TARVIQSMLK YASPALRAEI SEKLLPFTVE MCQSKYAQFC VQRMLKYGAP ATKAKLVDSL
     YGHIVRLAGH SIGSGLLDSM YQSATPNQRI YMRQEFYGDL YRKAKDSNVK TLSDTYKEAT
     NMKASILGSV KANLDHVANK QLVDSALVHA VMLEYLRACD EDEEKLEETV TAFAALVPHM
     LSTKEGSEAA VICFYKSTPK NRRAIIKNIK EHLLKIANHE HGHVFLISLL NALDDTKATK
     KAIYDHLHGD LKALMSSPYG RRVIQWLVAP GDTTCFHPEF IRTVEEGLAF GKKEKELRRK
     EILEQIEAPI AQSIAEDAAF WLSNSHIGLV TGDILNHIQG ESYEKAASAL AQVVVQPEWR
     ISADAAGPQP QDKKKPHNDV EAIIAQATKQ RRKLLYVESS SDDEDEDEDE DEESDDEGDE
     KEQKEAAADD AEPKVKKAKK EPKKPKAKEE EPAAPLVSGI EEAGMHIVLK KILKNDGKRE
     GTPFSQQLLQ NLSSDVLKAW LGVNRACFVL LKLVEECPAL LDDCKKAIAA ERSLSQILAD
     RKTPGAKLLA AKLDIGK