ID   PENKB_XENLA             Reviewed;         216 AA.
AC   P07194;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Proenkephalin-A-B;
DE   Contains:
DE     RecName: Full=Synenkephalin;
DE   Contains:
DE     RecName: Full=Met-enkephalin;
DE     AltName: Full=Opioid growth factor;
DE              Short=OGF;
DE   Contains:
DE     RecName: Full=Met-enkephalin-Arg-Gly-Tyr;
DE   Contains:
DE     RecName: Full=Met-enkephalin-Arg-Phe;
DE   Flags: Precursor; Fragment;
GN   Name=penk-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6547769; DOI=10.1038/310251a0;
RA   Martens G.J.M., Herbert E.;
RT   "Polymorphism and absence of Leu-enkephalin sequences in proenkephalin
RT   genes in Xenopus laevis.";
RL   Nature 310:251-254(1984).
CC   -!- FUNCTION: Enkephalin neuropeptides compete with and mimic the effects
CC       of opiate drugs. They play a role in a number of physiologic functions,
CC       including pain perception and responses to stress.
CC       {ECO:0000250|UniProtKB:P01210}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01210}.
CC   -!- PTM: The N-terminal domain contains 6 conserved cysteines thought to be
CC       involved in disulfide bonding and/or processing.
CC       {ECO:0000250|UniProtKB:P01210}.
CC   -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC       {ECO:0000305}.
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DR   EMBL; X00853; CAA25406.1; -; Genomic_DNA.
DR   AlphaFoldDB; P07194; -.
DR   PRIDE; P07194; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR006024; Opioid_neupept.
DR   InterPro; IPR000703; Proenkphlin_A.
DR   PANTHER; PTHR11438; PTHR11438; 1.
DR   PANTHER; PTHR11438:SF3; PTHR11438:SF3; 1.
DR   Pfam; PF01160; Opiods_neuropep; 1.
DR   PRINTS; PR01028; OPIOIDPRCRSR.
DR   PRINTS; PR01029; PENKAPRCRSR.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Endorphin;
KW   Neuropeptide; Opioid peptide; Reference proteome; Secreted.
FT   PEPTIDE         <1..47
FT                   /note="Synenkephalin"
FT                   /id="PRO_0000008307"
FT   PEPTIDE         50..54
FT                   /note="Met-enkephalin"
FT                   /id="PRO_0000008308"
FT   PEPTIDE         57..61
FT                   /note="Met-enkephalin"
FT                   /id="PRO_0000008309"
FT   PROPEP          64..85
FT                   /id="PRO_0000008310"
FT   PEPTIDE         86..90
FT                   /note="Met-enkephalin"
FT                   /id="PRO_0000008311"
FT   PROPEP          93..131
FT                   /id="PRO_0000008312"
FT   PEPTIDE         134..141
FT                   /note="Met-enkephalin-Arg-Gly-Tyr"
FT                   /id="PRO_0000008313"
FT   PROPEP          144..155
FT                   /id="PRO_0000008314"
FT   PEPTIDE         158..162
FT                   /note="Met-enkephalin"
FT                   /id="PRO_0000008315"
FT   PROPEP          165..175
FT                   /id="PRO_0000008316"
FT   PEPTIDE         178..182
FT                   /note="Met-enkephalin"
FT                   /id="PRO_0000008317"
FT   PROPEP          183..207
FT                   /id="PRO_0000008318"
FT   PEPTIDE         210..216
FT                   /note="Met-enkephalin-Arg-Phe"
FT                   /id="PRO_0000008319"
FT   REGION          114..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   216 AA;  24979 MW;  BB48865419AC4131 CRC64;
     ACTLECEGKL PSAKAWGTCK ELLQLTKLDG VQDGEKYQDN NDSHYIAKKY GGFMKRYGGF
     MKKMDELYHA EPEEDDAGGE ILAKNYGGFM KKEYDSNRDA SDLLRELLAT SGDPESAIYH
     DNNSETPGEM NKRYGGFMRG YRRSTDLEDE TRGIQKRYGG FMRRVGRPEW WQDYQKRYGG
     FMTRFTDSFL PSDEDGESYS KENPDMEKRY GGFMRF