ID   PENT_ANTYA              Reviewed;           5 AA.
AC   P84863;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   02-JUN-2021, entry version 16.
DE   RecName: Full=Yamamarin;
DE   AltName: Full=Growth-suppressing pentapeptide;
OS   Antheraea yamamai (Japanese oak silkmoth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Saturniinae; Saturniini; Antheraea.
OX   NCBI_TaxID=7121;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, DEVELOPMENTAL STAGE, AND AMIDATION AT GLY-5.
RA   Yang P., Abe S., Zhao Y., An Y., Suzuki K.;
RT   "Growth suppression of rat heptatoma cells by a pentapeptide from Antheraea
RT   yamamai.";
RL   J. Insect Biotechnol. Sericology 73:7-13(2004).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND AMIDATION AT GLY-5.
RC   TISSUE=Larva {ECO:0000269|Ref.2};
RA   Yang P., Abe S., Sato Y., Yamashita T., Matsuda F., Hamayasu T., Imai K.,
RA   Suzuki K.;
RT   "A palmitonyl conjugate of an insect pentapeptide causes growth arrest in
RT   mammalian cells and mimics the action of diapause hormone.";
RL   J. Insect Biotechnol. Sericology 76:63-69(2007).
CC   -!- FUNCTION: Suppresses growth in rat hepatoma cells and maintains
CC       diapause in insects. {ECO:0000269|Ref.1}.
CC   -!- DEVELOPMENTAL STAGE: Diapause. {ECO:0000269|Ref.1}.
CC   -!- PTM: Diapausing first instar larvae contain both amidated and non-
CC       amidated forms. {ECO:0000269|Ref.1, ECO:0000269|Ref.2}.
CC   -!- MASS SPECTROMETRY: Mass=571.858; Method=MALDI; Note=With amidation at
CC       Gly-5.; Evidence={ECO:0000269|Ref.2};
CC   -!- MASS SPECTROMETRY: Mass=572.846; Method=MALDI; Note=Without amidation
CC       at Gly-5.; Evidence={ECO:0000269|Ref.2};
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DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Growth regulation.
FT   PEPTIDE         1..5
FT                   /note="Yamamarin"
FT                   /evidence="ECO:0000269|Ref.2"
FT                   /id="PRO_0000245164"
FT   MOD_RES         5
FT                   /note="Glycine amide; partial"
FT                   /evidence="ECO:0000269|Ref.1, ECO:0000269|Ref.2"
SQ   SEQUENCE   5 AA;  573 MW;  686407205AC00000 CRC64;
     DILRG