ID   PEP18_ARGAU             Reviewed;          20 AA.
AC   P84749;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Astacin-like peptidase p18;
DE            EC=3.4.24.-;
DE   Flags: Fragment;
OS   Argiope aurantia (Black-and-yellow garden spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Araneoidea; Araneidae; Argiope.
OX   NCBI_TaxID=156844;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND COFACTOR.
RX   PubMed=16458560; DOI=10.1016/j.cbpb.2005.08.012;
RA   Foradori M.J., Tillinghast E.K., Smith J.S., Townley M.A., Mooney R.E.;
RT   "Astacin family metallopeptidases and serine peptidase inhibitors in spider
RT   digestive fluid.";
RL   Comp. Biochem. Physiol. 143B:257-268(2006).
CC   -!- FUNCTION: Active against casein. Has a role as a digestive enzyme.
CC       {ECO:0000269|PubMed:16458560}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000269|PubMed:16458560};
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DR   AlphaFoldDB; P84749; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR001506; Peptidase_M12A.
DR   PROSITE; PS51864; ASTACIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Metal-binding; Metalloprotease;
KW   Protease; Zinc.
FT   CHAIN           1..>20
FT                   /note="Astacin-like peptidase p18"
FT                   /id="PRO_0000078187"
FT   DOMAIN          1..>20
FT                   /note="Peptidase M12A"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01211"
FT   NON_TER         20
FT                   /evidence="ECO:0000303|PubMed:16458560"
SQ   SEQUENCE   20 AA;  2400 MW;  76DABADC3FE1E29C CRC64;
     NAIPGNYYRW PYAKVPYVID