ID   PEP1_THUOR              Reviewed;          58 AA.
AC   P20139;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Pepsin-1;
DE            EC=3.4.23.-;
DE   Flags: Precursor; Fragment;
OS   Thunnus orientalis (North Pacific bluefin tuna) (Thunnus thynnus
OS   orientalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Pelagiaria; Scombriformes; Scombridae; Thunnus.
OX   NCBI_TaxID=8238;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3142769; DOI=10.1111/j.1432-1033.1988.tb14369.x;
RA   Tanji M., Kageyama T., Takahashi K.;
RT   "Tuna pepsinogens and pepsins. Purification, characterization and amino-
RT   terminal sequences.";
RL   Eur. J. Biochem. 177:251-259(1988).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR   PIR; S01798; S01798.
DR   AlphaFoldDB; P20139; -.
DR   SMR; P20139; -.
DR   MEROPS; A01.057; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   Pfam; PF07966; A1_Propeptide; 1.
PE   1: Evidence at protein level;
KW   Aspartyl protease; Direct protein sequencing; Hydrolase; Protease; Zymogen.
FT   PROPEP          1..41
FT                   /note="Activation peptide"
FT                   /id="PRO_0000026001"
FT   CHAIN           42..>58
FT                   /note="Pepsin-1"
FT                   /id="PRO_0000026002"
FT   NON_TER         58
SQ   SEQUENCE   58 AA;  6703 MW;  EEC67C444B9B3A9F CRC64;
     LLQVPLEKGQ SAREYLQEQG LWEQYRLKYP YNPMAKFDPS FAVAGEPMTN DADLAYYG