PEP2_THUOR
ID PEP2_THUOR Reviewed; 72 AA.
AC P20140;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Pepsin-2;
DE EC=3.4.23.-;
DE Flags: Precursor; Fragment;
OS Thunnus orientalis (North Pacific bluefin tuna) (Thunnus thynnus
OS orientalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Pelagiaria; Scombriformes; Scombridae; Thunnus.
OX NCBI_TaxID=8238;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=3142769; DOI=10.1111/j.1432-1033.1988.tb14369.x;
RA Tanji M., Kageyama T., Takahashi K.;
RT "Tuna pepsinogens and pepsins. Purification, characterization and amino-
RT terminal sequences.";
RL Eur. J. Biochem. 177:251-259(1988).
CC -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR PIR; S01799; S01799.
DR AlphaFoldDB; P20140; -.
DR SMR; P20140; -.
DR MEROPS; A01.088; -.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; -; 1.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; PTHR47966; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR SUPFAM; SSF50630; SSF50630; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 1: Evidence at protein level;
KW Aspartyl protease; Direct protein sequencing; Hydrolase; Protease; Zymogen.
FT PROPEP 1..37
FT /note="Activation peptide"
FT /id="PRO_0000026003"
FT CHAIN 38..>72
FT /note="Pepsin-2"
FT /id="PRO_0000026004"
FT DOMAIN 53..>72
FT /note="Peptidase A1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01103"
FT NON_TER 72
SQ SEQUENCE 72 AA; 8445 MW; B985AAC76404FECA CRC64;
FHKLPLIKGK TAREELQERG LWEDYRKQYP YHPMAKFYQD GTEPMTNDAD LSYYGVVSIG
TPPQSFKVIF DT