ID   PEPC_PIG                Reviewed;          73 AA.
AC   P30879;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Gastricsin;
DE            EC=3.4.23.3;
DE   AltName: Full=Pepsinogen C;
DE   Flags: Precursor; Fragment;
GN   Name=PGC;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=1599954; DOI=10.1016/0167-4838(92)90339-f;
RA   Foltmann B., Drohse H.B., Nielsen P.K., James M.N.G.;
RT   "Separation of porcine pepsinogen A and progastricsin. Sequencing of the
RT   first 73 amino acid residues in progastricsin.";
RL   Biochim. Biophys. Acta 1121:75-82(1992).
CC   -!- FUNCTION: Hydrolyzes a variety of proteins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=More restricted specificity than pepsin A, but shows
CC         preferential cleavage at Tyr-|-Xaa bonds. High activity on
CC         hemoglobin.; EC=3.4.23.3;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR   PIR; S21754; S21754.
DR   AlphaFoldDB; P30879; -.
DR   SMR; P30879; -.
DR   STRING; 9823.ENSSSCP00000001761; -.
DR   MEROPS; A01.057; -.
DR   PaxDb; P30879; -.
DR   PRIDE; P30879; -.
DR   eggNOG; KOG1339; Eukaryota.
DR   InParanoid; P30879; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; PTHR47966; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   1: Evidence at protein level;
KW   Aspartyl protease; Digestion; Direct protein sequencing; Hydrolase;
KW   Protease; Reference proteome; Secreted; Zymogen.
FT   PROPEP          1..43
FT                   /note="Activation peptide"
FT                   /id="PRO_0000026065"
FT   CHAIN           44..>73
FT                   /note="Gastricsin"
FT                   /id="PRO_0000026066"
FT   DOMAIN          57..>73
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01103"
FT   NON_TER         73
SQ   SEQUENCE   73 AA;  8294 MW;  9B86BF3D2C05BCC6 CRC64;
     SVIKVPLKKL KSIRQAMKEK GLLEEFLKTH KYDPAQRYRI GDISVALEPM AYLEAAYFGE
     ISIGTPPQNF LVL