ID   PEPDA_STRP3             Reviewed;         465 AA.
AC   P0DD24; Q878G9; Q8K848;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Probable dipeptidase A;
DE            EC=3.4.13.19;
GN   Name=pepDA; OrderedLocusNames=SpyM3_0465;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid;
CC         Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC         ChEBI:CHEBI:77460; EC=3.4.13.19;
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. {ECO:0000305}.
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DR   EMBL; AE014074; AAM79072.1; -; Genomic_DNA.
DR   RefSeq; WP_011054318.1; NC_004070.1.
DR   AlphaFoldDB; P0DD24; -.
DR   SMR; P0DD24; -.
DR   MEROPS; C69.001; -.
DR   EnsemblBacteria; AAM79072; AAM79072; SpyM3_0465.
DR   KEGG; spg:SpyM3_0465; -.
DR   HOGENOM; CLU_014823_4_1_9; -.
DR   OMA; DLTYSHE; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   3: Inferred from homology;
KW   Dipeptidase; Hydrolase; Protease.
FT   CHAIN           1..465
FT                   /note="Probable dipeptidase A"
FT                   /id="PRO_0000220387"
FT   ACT_SITE        3
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   465 AA;  52905 MW;  2E7B1E725842FC2C CRC64;
     MACTTILVGK KASYDGSTMV ARTEDSQNGD FTPKKMIVVK PEDQPRHYRS VQSSFEMDLP
     DNPMTYTSVP DALGKDGIWA EAGVNEANVA MSATETITTN SRVLGADPLV ASGIGEEDMV
     TLVLPYIRSA REGVLRLGAI LEDYGTYESN GVAFSDEHDI WWLETIGGHH WIARRVPDDA
     YVTNPNQFGI DHFEFNNPED YLCSADLKDF IDTYHLDLTY SHEHFNPRYA FGSQRDKDRQ
     YNTPRVWIMQ KFLNPEIVQD PRSFALAWCQ KPYRKITVED VKYVLSSHYQ DTVYDPYGSE
     GTPVSKKVFR PIGINRTSQT AILHIRPNKP QEIAAIQWMA YGSMPFNTMV PFFTQVKTIP
     DYFANTYENV STDNFYWTNR LIAALADPHY NHHETDLDNY LEETMAKGHA MLHAVEAQLL
     AGETVDLEEE NQKMSDYVQG ETQTLLNKIL FDASNLMTNR FSLSD