ID   PEPDA_STRP6             Reviewed;         465 AA.
AC   Q5XD16;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Probable dipeptidase A;
DE            EC=3.4.13.19;
GN   Name=pepDA; OrderedLocusNames=M6_Spy0562;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid;
CC         Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC         ChEBI:CHEBI:77460; EC=3.4.13.19;
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. {ECO:0000305}.
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DR   EMBL; CP000003; AAT86697.1; -; Genomic_DNA.
DR   RefSeq; WP_011184349.1; NC_006086.1.
DR   AlphaFoldDB; Q5XD16; -.
DR   SMR; Q5XD16; -.
DR   MEROPS; C69.001; -.
DR   PRIDE; Q5XD16; -.
DR   EnsemblBacteria; AAT86697; AAT86697; M6_Spy0562.
DR   KEGG; spa:M6_Spy0562; -.
DR   HOGENOM; CLU_014823_4_1_9; -.
DR   OMA; DLTYSHE; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   3: Inferred from homology;
KW   Dipeptidase; Hydrolase; Protease.
FT   CHAIN           1..465
FT                   /note="Probable dipeptidase A"
FT                   /id="PRO_0000220388"
FT   ACT_SITE        3
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   465 AA;  52904 MW;  F453B738E3FF8876 CRC64;
     MACTTILVGK KASYDGSTMV ARTEDSQNGD FTPKKMIVVK PEDQPRHYRS VQSSFEMDLP
     DNPMTYTSVP DALGKDGIWA EAGVNEANVT MSATETITTN SRVLGADPLV ASGIGEEDMV
     TLVLPYIRSA REGVLRLGAI LEDYGTYESN GVAFSDEHDI WWLETIGGHH WIARRVPDDA
     YVTNPNQFGI DHFEFNNPED YLCSADLKDF IDTYHLDLTY SHEHFNPRYA FGSQRDKDRH
     YNTPRAWIMQ KFLNPEIVQD PRSFALAWCQ KPYRKITVED VKYVLSSHYQ DMGYDPYGSE
     GTPVSKKVFR PIGINRTSQT AILHIRPNKP QEIAAIQWMA YGSMPFNTMV PFFTQVKTIP
     DYFANTYENV STDNFYWTNR LIAALADPHY NHHETDLDNY LEETMAKGHA MLHAVEAQLL
     AGETVDLEEE NQKMSDYVQG ETQTLLNKIL FDASNLMTNR FSLSD