ID   PEPDA_STRP8             Reviewed;         472 AA.
AC   Q8P1N3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Probable dipeptidase A;
DE            EC=3.4.13.19;
GN   Name=pepDA; OrderedLocusNames=spyM18_0780;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid;
CC         Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC         ChEBI:CHEBI:77460; EC=3.4.13.19;
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. {ECO:0000305}.
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DR   EMBL; AE009949; AAL97447.1; -; Genomic_DNA.
DR   RefSeq; WP_011017593.1; NC_003485.1.
DR   AlphaFoldDB; Q8P1N3; -.
DR   SMR; Q8P1N3; -.
DR   MEROPS; C69.001; -.
DR   KEGG; spm:spyM18_0780; -.
DR   HOGENOM; CLU_014823_4_2_9; -.
DR   OMA; DLTYSHE; -.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   3: Inferred from homology;
KW   Dipeptidase; Hydrolase; Protease.
FT   CHAIN           1..472
FT                   /note="Probable dipeptidase A"
FT                   /id="PRO_0000220389"
FT   ACT_SITE        10
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   472 AA;  53788 MW;  C35DE6A4E5B152E4 CRC64;
     MDKKIQRFSC TTILVGKKAS YDGSTMVART EDSQNGDFTP KKMIVVKPED QPRHYRSVQS
     SFEMDLPDNP MTYTSVPDAL GKDGIWAEAG VNEANVTMSA TETITTNSRV LGADPLVASG
     IGEEDMVTLV LPYIRSAREG VLRLGAILED YGTYESNGVA FSDEHDIWWL ETIGGHHWIA
     RRVPDDAYVT NPNQFGIDHF EFNNPEDYLC SADLKDFIDT YHLDLTYSHE HFNPRYAFGS
     QRDKDRHYNT PRAWIMQKFL NPEIVQDPRS FALAWCQKPY RKITVEDVKY VLSSHYQDTG
     YDPYGSEGTP VSKKVFRPIG INRTSQTAIL HIRPNKPQEI AAIQWIAYGS MPFNTMVPFF
     TQVKTIPDYF ANTYENVSTD NFYWTNRLIA ALADPHYNHH ETDLDNYLEE TMAKGHAMLH
     AVEAQLLAGE TVDLEEENQK MSDYVQGETQ TLLNKILFDA SNLMTNRFSL SD