ID   PEPDA_STRPQ             Reviewed;         465 AA.
AC   P0DD25; Q878G9; Q8K848;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Probable dipeptidase A;
DE            EC=3.4.13.19;
GN   Name=pepDA; OrderedLocusNames=SPs1390;
OS   Streptococcus pyogenes serotype M3 (strain SSI-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=193567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1;
RX   PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H.,
RA   Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-
RT   scale genomic rearrangement in invasive strains and new insights into phage
RT   evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid;
CC         Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC         ChEBI:CHEBI:77460; EC=3.4.13.19;
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC64485.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000034; BAC64485.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011054318.1; NC_004606.1.
DR   AlphaFoldDB; P0DD25; -.
DR   SMR; P0DD25; -.
DR   MEROPS; C69.001; -.
DR   KEGG; sps:SPs1390; -.
DR   HOGENOM; CLU_014823_4_2_9; -.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   3: Inferred from homology;
KW   Dipeptidase; Hydrolase; Protease.
FT   CHAIN           1..465
FT                   /note="Probable dipeptidase A"
FT                   /id="PRO_0000411450"
FT   ACT_SITE        3
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   465 AA;  52905 MW;  2E7B1E725842FC2C CRC64;
     MACTTILVGK KASYDGSTMV ARTEDSQNGD FTPKKMIVVK PEDQPRHYRS VQSSFEMDLP
     DNPMTYTSVP DALGKDGIWA EAGVNEANVA MSATETITTN SRVLGADPLV ASGIGEEDMV
     TLVLPYIRSA REGVLRLGAI LEDYGTYESN GVAFSDEHDI WWLETIGGHH WIARRVPDDA
     YVTNPNQFGI DHFEFNNPED YLCSADLKDF IDTYHLDLTY SHEHFNPRYA FGSQRDKDRQ
     YNTPRVWIMQ KFLNPEIVQD PRSFALAWCQ KPYRKITVED VKYVLSSHYQ DTVYDPYGSE
     GTPVSKKVFR PIGINRTSQT AILHIRPNKP QEIAAIQWMA YGSMPFNTMV PFFTQVKTIP
     DYFANTYENV STDNFYWTNR LIAALADPHY NHHETDLDNY LEETMAKGHA MLHAVEAQLL
     AGETVDLEEE NQKMSDYVQG ETQTLLNKIL FDASNLMTNR FSLSD