ID   PEPDB_STRP3             Reviewed;         499 AA.
AC   P0DD26; Q79W34; Q8K5M7;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Probable dipeptidase B;
DE            EC=3.4.13.19;
GN   Name=pepDB; OrderedLocusNames=SpyM3_1763;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid;
CC         Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC         ChEBI:CHEBI:77460; EC=3.4.13.19;
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. {ECO:0000305}.
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DR   EMBL; AE014074; AAM80370.1; -; Genomic_DNA.
DR   RefSeq; WP_011055067.1; NC_004070.1.
DR   AlphaFoldDB; P0DD26; -.
DR   SMR; P0DD26; -.
DR   MEROPS; C69.002; -.
DR   EnsemblBacteria; AAM80370; AAM80370; SpyM3_1763.
DR   KEGG; spg:SpyM3_1763; -.
DR   HOGENOM; CLU_014823_0_1_9; -.
DR   OMA; DKFAVFP; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   3: Inferred from homology;
KW   Dipeptidase; Hydrolase; Protease.
FT   CHAIN           1..499
FT                   /note="Probable dipeptidase B"
FT                   /id="PRO_0000220391"
FT   ACT_SITE        26
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  55554 MW;  06AADE28F21F0D02 CRC64;
     MINKKISLGV LSILTAFSLQ SVSYACTGFI IGKDLTKDGS LLYGRTEDLE PHHNKNFIVR
     LAKDNPAGEK WKDPSNGFEY PLPEHSYRYS AIPDVTPNKG VYDEAGFNEF GVSMSATVST
     SANDAIQKID PYVKNGLAES SMASVILPSV KTAREGVALI AKIVTEKGAA EGNIVTLADK
     DGIWYMEILS GHQYVAIKFP DDKYAVFPNT FYLGHVDFND KENTIASEDV EKVAKKAKSY
     TEVDGKFHIA KSYNPPLNDA NRSRSFSGIK SLDPDSKVTY KDSNYELLQS TDKTFSLEDA
     MKLQRNRFEG LDLKPLDQMA LDGKGKPKSK KAVKGYAYPI SNPNVMEAHI FQLKKDIPAE
     LGGGVMWLSI GSPRNAPYLP YLGNISRTYE AYQEKSTQYN DKSWYWTVSH INDLVAAHPK
     PFGTKVIDEM KGLEKTWIAE QDKTTKEISD LVVSDPKAAQ EKADKISLDR AEKTFKRLKA
     IEAKLVKEKP KNKKGLNRS