ID   PEPDB_STRP8             Reviewed;         499 AA.
AC   Q8NZ57;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Probable dipeptidase B;
DE            EC=3.4.13.19;
GN   Name=pepDB; OrderedLocusNames=spyM18_2126;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid;
CC         Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC         ChEBI:CHEBI:77460; EC=3.4.13.19;
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. {ECO:0000305}.
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DR   EMBL; AE009949; AAL98580.1; -; Genomic_DNA.
DR   RefSeq; WP_011018292.1; NC_003485.1.
DR   AlphaFoldDB; Q8NZ57; -.
DR   SMR; Q8NZ57; -.
DR   MEROPS; C69.002; -.
DR   KEGG; spm:spyM18_2126; -.
DR   HOGENOM; CLU_014823_0_1_9; -.
DR   OMA; DKFAVFP; -.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   3: Inferred from homology;
KW   Dipeptidase; Hydrolase; Protease.
FT   CHAIN           1..499
FT                   /note="Probable dipeptidase B"
FT                   /id="PRO_0000220393"
FT   ACT_SITE        26
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  55495 MW;  CEF3478F37928F19 CRC64;
     MINKKISLGV LSILTAFSLQ SVSYACTGFI IGKDLTKDGS LLYGRTEDLE PHHNKNFIVR
     LAKDNPAGEK WKDLSNGFEY PLPEHSYRYS AIPDVTPNKG VYDEAGFNEC GVSMSATVSA
     SANDAIQKID PYVKNGLAES SMASVILPSV KTAREGVALI AKIVTEKGAA EGNIVTLADK
     DGIWYMEILS GHQYVAIKFP DDKYAVFPNT FYLGHVDFND KENTIASEDV EKVAKKAKSY
     IEVDGKFHIA KSYNPPLNDA NRSRSFSGIK SLDPDSKVTY KDSNYELLQS TDKTFSLEDA
     MKLQRNRFEG LDLKPLDQMA LDGKGKPKSK KAVKGYAYPI SNPNVMEAHI FQLKKDIPAE
     LGGGVMWLSI GSPRNAPYLP YLGNISRTYE AYQEKSTQYN DKSWYWTVSH INDLVAAHPK
     PFGTKVIDEM KGLEKTWIAE QDKSTKEISD LVVSDPKAAQ EKADKISLDR AEKTFKRLKA
     IEAKLVEEKP KNKKGLNRS