ID   PEPF_MYCPN              Reviewed;         611 AA.
AC   P54125;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Oligoendopeptidase F homolog;
DE            EC=3.4.24.-;
GN   Name=pepF; OrderedLocusNames=MPN_197; ORFNames=MP634;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8604303; DOI=10.1093/nar/24.4.628;
RA   Hilbert H., Himmelreich R., Plagens H., Herrmann R.;
RT   "Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma
RT   pneumoniae comprising the dnaA region, the atp operon and a cluster of
RT   ribosomal protein genes.";
RL   Nucleic Acids Res. 24:628-639(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M3B family. {ECO:0000305}.
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DR   EMBL; U34795; AAC43684.1; -; Genomic_DNA.
DR   EMBL; U00089; AAB96282.1; -; Genomic_DNA.
DR   PIR; S62811; S62811.
DR   RefSeq; NP_109885.1; NC_000912.1.
DR   RefSeq; WP_010874554.1; NC_000912.1.
DR   AlphaFoldDB; P54125; -.
DR   SMR; P54125; -.
DR   STRING; 272634.MPN_197; -.
DR   EnsemblBacteria; AAB96282; AAB96282; MPN_197.
DR   KEGG; mpn:MPN_197; -.
DR   PATRIC; fig|272634.6.peg.215; -.
DR   HOGENOM; CLU_021290_2_0_14; -.
DR   OMA; YRQTMFA; -.
DR   BioCyc; MPNE272634:G1GJ3-315-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1370.20; -; 1.
DR   InterPro; IPR013647; OligopepF_N_dom.
DR   InterPro; IPR042088; OligoPept_F_C.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   InterPro; IPR004438; Peptidase_M3B.
DR   PANTHER; PTHR11804; PTHR11804; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   Pfam; PF08439; Peptidase_M3_N; 1.
DR   TIGRFAMs; TIGR00181; pepF; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..611
FT                   /note="Oligoendopeptidase F homolog"
FT                   /id="PRO_0000078168"
FT   ACT_SITE        385
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         384
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         388
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         391
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   611 AA;  70959 MW;  8DB896D570BB215D CRC64;
     MNNQYNWNLE VLLNGKSLAD NFTELKQLSE QEKALYDGGA CFQTKAKFTE FLQLQEKIEV
     LENRYSNFLS NKHAENSLDK TINDALFQYE MFKSEHALVF VDFEKNLFKH EKVIRAYLQD
     PALKQYQRDF ELVWRNKKHQ IDPASQKLLA QISPAWNQAD KIFNVLSTAD LNLQPVVYKG
     KTYVINAVSD YQSLLENKDR GLREAAYKVW LEIYWPTRNT LSVSLVENYI QLETFAKLKK
     HPNYIAKTAF DDEIDVAFID FVYEQVASFA PTFKAFQSLR KQIYKHVLKL DKAQPWDLSV
     PLFKASGDYT IEQAQTDALK ILAPMGSEYL EVVKEAFRER WISWLPDKNK YTGAYSISNV
     KGLDHYFILM NFDKTRASLN TLVHELGHSV HSWYASKYQT QNLDPTIFYA EIASICNELL
     LCYHDIINYE NRNPQQLIRS LMEQISHFFG ATTRQLMFSQ FEQDTLKLIQ QNQKPDFKTL
     VEIYGKTAIK YQAANADAIT KKLKQTKYQK SLAYITSIPH FYAGNFYVYK YAIGQVVGTL
     VGKKLSAGDS NMLAAYKRFL SSGSTLPPLE TIKLLGIDLT QPEPWQEAHA ELKRWIKLVQ
     TAFKQLQHKK R