ID   PEPG_LACDL              Reviewed;         437 AA.
AC   P94869;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Aminopeptidase G;
DE            EC=3.4.22.-;
GN   Name=pepG;
OS   Lactobacillus delbrueckii subsp. lactis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=29397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 7290;
RX   PubMed=9043129; DOI=10.1099/00221287-143-2-527;
RA   Klein J.R., Schick J., Henrich B., Plapp R.;
RT   "Lactobacillus delbrueckii subsp. lactis DSM7290 pepG gene encodes a novel
RT   cysteine aminopeptidase.";
RL   Microbiology 143:527-537(1997).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089}.
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DR   EMBL; Z71782; CAA96465.1; -; Genomic_DNA.
DR   AlphaFoldDB; P94869; -.
DR   SMR; P94869; -.
DR   MEROPS; C01.089; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00585; Peptidase_C1B; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR004134; Peptidase_C1B.
DR   PANTHER; PTHR10363; PTHR10363; 1.
DR   Pfam; PF03051; Peptidase_C1_2; 1.
DR   PIRSF; PIRSF005700; PepC; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Cytoplasm; Hydrolase; Protease; Thiol protease.
FT   CHAIN           1..437
FT                   /note="Aminopeptidase G"
FT                   /id="PRO_0000050597"
FT   ACT_SITE        70
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        361
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        382
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   437 AA;  49706 MW;  2099C62E57181FC5 CRC64;
     MSHELTLQEL AEFSANFNAD PKNQVIARAA ARSGVLEASY NERVAGRLTR VFSTELPTDN
     VTNQKQSGRC WLFSTLNVLR HDFGAKHKAK NFTLSQSYNF FWDKLERANL FYEKVIETAD
     KPLDDREVRS YFDFAGHDGG QWHMAISLVK KYGVVPSYVM PESFNTSATN GLASALADKE
     RKDALALRRL AQAGDQEGLE KARKTFLNEI YRMVAIAVGE PPKTFDLEYR DDDKNYHLEK
     NLTPVSFFNK YFDVDLDDYV VLTNAPDHEY GKLYHLGAED NVEGGSPILF LNVPMEYLEQ
     TAVAQLKDGE AVWFGNDVLR QMDRKTGYLD TDLYKLEDLF DVDLSLSKAD RLATGAGEVS
     HAMTLVGVDE DKGDIRQWKV ENSWGDKSGE KGFFVMSHNW FKEYVYEVVV HKKYLTKDQQ
     ELLSSTPVEL APWDSLA