ID   PEPL1_PONAB             Reviewed;         523 AA.
AC   Q5R7G6;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Probable aminopeptidase NPEPL1;
DE            EC=3.4.11.-;
DE   AltName: Full=Aminopeptidase-like 1;
GN   Name=NPEPL1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably catalyzes the removal of unsubstituted N-terminal
CC       amino acids from various peptides. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M17 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH92294.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR860151; CAH92294.1; ALT_INIT; Transcribed_RNA.
DR   AlphaFoldDB; Q5R7G6; -.
DR   SMR; Q5R7G6; -.
DR   STRING; 9601.ENSPPYP00000012484; -.
DR   MEROPS; M17.006; -.
DR   eggNOG; KOG2597; Eukaryota.
DR   HOGENOM; CLU_013734_3_1_1; -.
DR   InParanoid; Q5R7G6; -.
DR   OrthoDB; 562530at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00433; Peptidase_M17; 1.
DR   InterPro; IPR011356; Leucine_aapep/pepB.
DR   InterPro; IPR041417; NPEPL1_N.
DR   InterPro; IPR000819; Peptidase_M17_C.
DR   PANTHER; PTHR11963; PTHR11963; 1.
DR   Pfam; PF18295; Pdase_M17_N2; 1.
DR   Pfam; PF00883; Peptidase_M17; 1.
DR   PRINTS; PR00481; LAMNOPPTDASE.
DR   PROSITE; PS00631; CYTOSOL_AP; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Hydrolase; Manganese; Metal-binding; Protease;
KW   Reference proteome; Zinc.
FT   CHAIN           1..523
FT                   /note="Probable aminopeptidase NPEPL1"
FT                   /id="PRO_0000165830"
FT   ACT_SITE        272
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        346
FT                   /evidence="ECO:0000255"
FT   BINDING         260
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         265
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         265
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         283
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         342
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         344
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         344
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   523 AA;  55847 MW;  1B00DFB02D169C0C CRC64;
     MANVGLQFQA SAGDSDPQSR PLLLLGQLHH LHRVPWSHVR GKLQPRVTEE LWQAALSTLN
     PNPTDSCPLY LNYATVAALP CRVSRHNSPS AAHFITRLVR TCLPPGAHRC IVMVCEQPEV
     FASACALARA FPLFTHRSGA SRRLEKKTVT VEFFLVGQDN GPVEVSTLQC LANATDGVRL
     AARIVDTPCN EMNTDTFLEE INKVGKELGI IPTIIRDEEL KTRGFGGIYG VGKAALHPPA
     LAVLSHTPDG ATQTIAWVGK GIVYDTGGLS IKGKTTMPGM KRDCGGAAAV LGAFRAAIKQ
     GFKDNLHAVF CLAENSVGPN ATRPDDIHLL YSGKTVEINN TDAEGRLVLA DGVSYACKDL
     GADIILDMAT LTGAQGIATG KYHAAVLTNS AEWEAACVKA GRKCGDLVHP LVYCPELHFS
     EFTSAVADMK NSVADRDNSP SSCAGLFIAS HIGFDWPGVW VHLDIAAPVH AGERATGFGV
     ALLLALFGRA SEDPLLNLVS PLGCEVDVEE GDVGRDSKRR RLV