PEPT1_DERMI
ID PEPT1_DERMI Reviewed; 30 AA.
AC P16312;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Peptidase 1;
DE EC=3.4.22.65;
DE AltName: Full=Allergen Der m I;
DE AltName: Full=Major mite fecal allergen Der m 1;
DE AltName: Allergen=Der m 1;
DE Flags: Fragment;
GN Name=DERM1;
OS Dermatophagoides microceras (House dust mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC Pyroglyphidae; Dermatophagoidinae; Dermatophagoides.
OX NCBI_TaxID=6955;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=3372999;
RA Lind P., Hansen O.C., Horn N.;
RT "The binding of mouse hybridoma and human IgE antibodies to the major fecal
RT allergen, Der p I, of Dermatophagoides pteronyssinus. Relative binding site
RT location and species specificity studied by solid-phase inhibition assays
RT with radiolabeled antigen.";
RL J. Immunol. 140:4256-4262(1988).
CC -!- FUNCTION: Thiol protease that hydrolyzes proteins, with a preference
CC for Phe or basic residues.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Broad endopeptidase specificity.; EC=3.4.22.65;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,
CC ECO:0000255|PROSITE-ProRule:PRU10090}.
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DR PIR; B27634; B27634.
DR AlphaFoldDB; P16312; -.
DR Allergome; 309; Der m 1.
DR Allergome; 3257; Der m 1.0101.
DR MEROPS; C01.027; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Hydrolase; Protease; Secreted;
KW Thiol protease.
FT CHAIN 1..>30
FT /note="Peptidase 1"
FT /id="PRO_0000050547"
FT NON_TER 30
SQ SEQUENCE 30 AA; 3314 MW; D60B742967194886 CRC64;
TQACRINSGN VPSELDLRSL RTVTPIRMQG