PEPT1_EURMA
ID PEPT1_EURMA Reviewed; 321 AA.
AC P25780; Q9TZZ3; Q9TZZ4; Q9UBA0;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Peptidase 1;
DE EC=3.4.22.65;
DE AltName: Full=Allergen Eur m I;
DE AltName: Full=Mite group 1 allergen Eur m 1;
DE AltName: Allergen=Eur m 1;
DE Flags: Precursor;
GN Name=EURM1;
OS Euroglyphus maynei (Mayne's house dust mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC Pyroglyphidae; Pyroglyphinae; Euroglyphus.
OX NCBI_TaxID=6958;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (EUR M 1.0101 AND EUR M 1.0102).
RX PubMed=9925958; DOI=10.1159/000024026;
RA Smith W., Mills K., Hazell L., Hart B.J., Thomas W.;
RT "Molecular analysis of the group 1 and 2 allergens from the house dust
RT mite, Euroglyphus maynei.";
RL Int. Arch. Allergy Immunol. 118:15-22(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 99-309.
RX PubMed=1483062; DOI=10.1159/000236349;
RA Kent N.A., Hill M.R., Keen J.N., Holland P.W., Hart B.J.;
RT "Molecular characterisation of group I allergen Eur m I from house dust
RT mite Euroglyphus maynei.";
RL Int. Arch. Allergy Immunol. 99:150-152(1992).
CC -!- FUNCTION: Probable thiol protease.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Broad endopeptidase specificity.; EC=3.4.22.65;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,
CC ECO:0000255|PROSITE-ProRule:PRU10090}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC82352.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF047610; AAC82351.1; -; mRNA.
DR EMBL; AF047611; AAC82352.1; ALT_INIT; mRNA.
DR EMBL; AF047612; AAC82353.1; -; mRNA.
DR EMBL; X60073; CAA42677.1; -; Genomic_DNA.
DR PIR; S21864; S21864.
DR AlphaFoldDB; P25780; -.
DR SMR; P25780; -.
DR Allergome; 1359; Eur m 1.0101.
DR Allergome; 1360; Eur m 1.0102.
DR Allergome; 338; Eur m 1.
DR MEROPS; C01.073; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 1: Evidence at protein level;
KW Allergen; Disulfide bond; Glycoprotein; Hydrolase; Protease; Secreted;
KW Signal; Thiol protease; Zymogen.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..98
FT /id="PRO_0000026378"
FT CHAIN 99..321
FT /note="Peptidase 1"
FT /id="PRO_0000026379"
FT ACT_SITE 133
FT /evidence="ECO:0000250"
FT ACT_SITE 269
FT /evidence="ECO:0000250"
FT ACT_SITE 289
FT /evidence="ECO:0000250"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 130..170
FT /evidence="ECO:0000250"
FT VARIANT 36
FT /note="T -> S (in Eur m 1.0102)"
FT VARIANT 126
FT /note="M -> N (in Eur m 1.0102)"
FT VARIANT 320
FT /note="M -> I (in Eur m 1.0102)"
SQ SEQUENCE 321 AA; 36290 MW; 6CFD44FEC725999E CRC64;
MKIILAIASL LVLSAVYARP ASIKTFEEFK KAFNKTYATP EKEEVARKNF LESLKYVESN
KGAINHLSDL SLDEFKNQFL MNANAFEQLK TQFDLNAETY ACSINSVSLP SELDLRSLRT
VTPIRMQGGC GSCWAFSGVA STESAYLAYR NMSLDLAEQE LVDCASQNGC HGDTIPRGIE
YIQQNGVVQE HYYPYVAREQ SCHRPNAQRY GLKNYCQISP PDSNKIRQAL TQTHTAVAVI
IGIKDLNAFR HYDGRTIMQH DNGYQPNYHA VNIVGYGNTQ GVDYWIVRNS WDTTWGDNGY
GYFAANINLM MIEQYPYVVM L
