ID   PEPW_LACDL              Reviewed;         437 AA.
AC   P94868;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Aminopeptidase W;
DE            EC=3.4.22.-;
GN   Name=pepW;
OS   Lactobacillus delbrueckii subsp. lactis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=29397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 7290;
RX   PubMed=9043129; DOI=10.1099/00221287-143-2-527;
RA   Klein J.R., Schick J., Henrich B., Plapp R.;
RT   "Lactobacillus delbrueckii subsp. lactis DSM7290 pepG gene encodes a novel
RT   cysteine aminopeptidase.";
RL   Microbiology 143:527-537(1997).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088}.
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DR   EMBL; Z71782; CAA96464.1; -; Genomic_DNA.
DR   AlphaFoldDB; P94868; -.
DR   SMR; P94868; -.
DR   MEROPS; C01.091; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00585; Peptidase_C1B; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR004134; Peptidase_C1B.
DR   PANTHER; PTHR10363; PTHR10363; 1.
DR   Pfam; PF03051; Peptidase_C1_2; 1.
DR   PIRSF; PIRSF005700; PepC; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Cytoplasm; Hydrolase; Protease; Thiol protease.
FT   CHAIN           1..437
FT                   /note="Aminopeptidase W"
FT                   /id="PRO_0000050599"
FT   ACT_SITE        70
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
FT   ACT_SITE        361
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
FT   ACT_SITE        382
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
SQ   SEQUENCE   437 AA;  50073 MW;  2D2F3DF9060514CE CRC64;
     MTHELSPQLL ESFSRDFNAD PKNQVISRAA RRSGLLEAAY NPAVSQRLNR TFSIELDTDN
     VTNQQQSGRC WLFSTLNVVR HNFGKANKAK NFTFSQSYNF FWDKIERANY FYDRIIATAD
     RPLTDRTVRG YFDWCQTDGG QWHMAASLIA KYGVVPRYAM PESFNSNHSQ ALDMVLADKE
     RKDALTLRRL AQADDQEKLE AARTDFLSQI YRIMATALGE PPKTFDLEFR DDDKNYHLDK
     GLTPVQFYKK YCATDLDDYV VLANAPDHEM NRVLHLGFED NIKGGYPNLF INVPMEYLED
     AAIAQLKDGE AVWFGNAVGR QMDRKTGFMD LDLYQLDQLL DIDSHLSKAD RLATGIGESS
     HDMALVGVDV DGGQVRQWKV ENSWGDKSGE KGYFTMSADW FREYTYEVAV QKKHVPAEIL
     DLLKNQPIEL DPWDSLI