ID   PERA_ECO27              Reviewed;         274 AA.
AC   P43459; B7UTE7;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Transcriptional activator PerA;
GN   Name=perA; OrderedLocusNames=E2348_P1_020;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OG   Plasmid pMAR2.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7729884; DOI=10.1128/iai.63.5.1767-1776.1995;
RA   Gomez-Duarte O.G., Kaper J.B.;
RT   "A plasmid-encoded regulatory region activates chromosomal eaeA expression
RT   in enteropathogenic Escherichia coli.";
RL   Infect. Immun. 63:1767-1776(1995).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RA   Kaper J.B.;
RL   Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/jb.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA   Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA   Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Could help in the transcriptional activator of eaeA
CC       expression in enteropathogenic E.coli. However, it seems that it is
CC       PerC which acts as an activator.
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DR   EMBL; Z48561; CAA88445.1; -; Genomic_DNA.
DR   EMBL; FM180569; CAS07456.1; -; Genomic_DNA.
DR   RefSeq; WP_000958124.1; NC_011603.1.
DR   RefSeq; YP_001965397.1; NC_010862.1.
DR   AlphaFoldDB; P43459; -.
DR   SMR; P43459; -.
DR   EnsemblBacteria; CAS07456; CAS07456; E2348_P1_020.
DR   KEGG; ecg:E2348_P1_020; -.
DR   HOGENOM; CLU_000445_81_4_6; -.
DR   OMA; FQISHRC; -.
DR   PHI-base; PHI:3803; -.
DR   Proteomes; UP000008205; Plasmid pMAR2.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Plasmid; Transcription; Transcription regulation.
FT   CHAIN           1..274
FT                   /note="Transcriptional activator PerA"
FT                   /id="PRO_0000194545"
FT   DOMAIN          168..265
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        185..206
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        232..255
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   274 AA;  31684 MW;  68F76DDA4CD4CBDC CRC64;
     MLTSKKEMQS SENKQEENLA LLLTNYISYQ NIVIFTGGNQ FKIRNKKEFT EYTIESNSLF
     FLAKNTHWDM EIVGIDNSNP YRKIIIDDAL IKLLHSISSD DSCYVKKKIF TANLNEMQLN
     IVSNIITDIK YSGNNKKIFK ILYLLSFFND YNDIVNVILS ASSKSIVDRV IKVIELDISK
     NWKLGDVSSS MFMSDSCLRK QLNKENLTFK KIMLDIKMKH ASLFLRTTDK NIDEISCLVG
     FNSTSYFIKV FKEYYNTTPK KYNGVYSITQ GTLP