ID   PERE_PIG                Reviewed;          38 AA.
AC   P80550;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   02-DEC-2020, entry version 65.
DE   RecName: Full=Eosinophil peroxidase;
DE            Short=EPO;
DE            EC=1.11.1.7;
DE   Contains:
DE     RecName: Full=Eosinophil peroxidase light chain;
DE   Contains:
DE     RecName: Full=Eosinophil peroxidase heavy chain;
DE   Flags: Fragments;
GN   Name=EPX; Synonyms=EPER;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=8645990; DOI=10.1159/000237277;
RA   Fornhem C., Peterson C.G.B., Alving K.;
RT   "Isolation and characterization of porcine cationic eosinophil granule
RT   proteins.";
RL   Int. Arch. Allergy Immunol. 110:132-142(1996).
CC   -!- FUNCTION: Mediates tyrosine nitration of secondary granule proteins in
CC       mature resting eosinophils. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2
CC         H2O; Xref=Rhea:RHEA:56136, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:139520, ChEBI:CHEBI:139521; EC=1.11.1.7;
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC       Note=Binds 1 Ca(2+) ion per heterodimer. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000250};
CC       Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per
CC       heterodimer. {ECO:0000250};
CC   -!- SUBUNIT: Tetramer of two light chains and two heavy chains.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of
CC       eosinophils.
CC   -!- SIMILARITY: Belongs to the peroxidase family. XPO subfamily.
CC       {ECO:0000305}.
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DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Hydrogen peroxide; Iron; Metal-binding;
KW   Oxidoreductase; Peroxidase; Reference proteome.
FT   CHAIN           <1..>13
FT                   /note="Eosinophil peroxidase light chain"
FT                   /id="PRO_0000023645"
FT   CHAIN           14..>38
FT                   /note="Eosinophil peroxidase heavy chain"
FT                   /id="PRO_0000023646"
FT   NON_CONS        13..14
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         38
SQ   SEQUENCE   38 AA;  4342 MW;  4BAA4744122C6789 CRC64;
     GDKYRXIXGR XNNVDXEKTX AQLPPXFPIK IPPNDXRI