ID   PERI4_PERAM             Reviewed;          13 AA.
AC   C0HLK9;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Periplanetasin-4 {ECO:0000303|PubMed:28949065};
DE            Short=Peri-4 {ECO:0000303|PubMed:28949065};
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS, FUNCTION, AND INDUCTION.
RX   PubMed=27167617; DOI=10.1371/journal.pone.0155304;
RA   Kim I.W., Lee J.H., Subramaniyam S., Yun E.Y., Kim I., Park J., Hwang J.S.;
RT   "De Novo Transciptome Analysis and Detection of Antimicrobial Peptides of
RT   the American Cockroach Periplaneta americana (Linnaeus).";
RL   PLoS ONE 11:E0155304-E0155304(2016).
RN   [2] {ECO:0000305}
RP   SYNTHESIS, AND FUNCTION.
RX   PubMed=28949065; DOI=10.1002/psc.3046;
RA   Yoon I.N., Lu L.F., Hong J., Zhang P., Kim D.H., Kang J.K., Hwang J.S.,
RA   Kim H.;
RT   "The American cockroach peptide periplanetasin-4 inhibits Clostridium
RT   difficile toxin A-induced cell toxicities and inflammatory responses in the
RT   mouse gut.";
RL   J. Pept. Sci. 23:833-839(2017).
RN   [3] {ECO:0000305}
RP   SYNTHESIS, AND FUNCTION.
RX   PubMed=30962256; DOI=10.1042/bcj20180933;
RA   Lee H., Hwang J.S., Lee D.G.;
RT   "Periplanetasin-4, a novel antimicrobial peptide from the cockroach,
RT   inhibits communications between mitochondria and vacuoles.";
RL   Biochem. J. 476:1267-1284(2019).
CC   -!- FUNCTION: Antimicrobial peptide which displays antifungal and
CC       antibacterial activity (PubMed:27167617, PubMed:28949065,
CC       PubMed:30962256). Has antibacterial activity against the Gram-negative
CC       bacterium E.coli ATCC 11775 (MIC=64 ug/ml), the Gram-positive bacterium
CC       S.aureus ATCC 25923 (MIC=64 ug/ml), and has antifungal activity against
CC       C.albicans ATCC 14053 (MIC=64 ug/ml) (PubMed:27167617). Has antifungal
CC       activity against C.albicans ATCC 90028 (MIC=5 uM), C.parapsilosis ATCC
CC       22019 (MIC=5 uM), T.beigelii KCTC 7707 (MIC=2.5 uM), M.furfur KCTC 7744
CC       (MIC=5 uM), A.flavus KCTC 6905 (MIC=10 uM) and A.fumigatus KCTC 6145
CC       (MIC=5 uM) (PubMed:30962256). In C.albicans, induces oxidative damage
CC       through the generation of reactive oxygen species (ROS) which leads to
CC       necrosis and the activation of apoptotic signaling mechanisms such as
CC       phosphatidylserine exposure, lipid peroxidation, caspase activation,
CC       vacuole and mitochondria dysfunction, however it does not induce DNA
CC       fragmentation (PubMed:30962256). {ECO:0000269|PubMed:27167617,
CC       ECO:0000269|PubMed:28949065, ECO:0000269|PubMed:30962256}.
CC   -!- INDUCTION: Up-regulated by infection with E.coli.
CC       {ECO:0000269|PubMed:27167617}.
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DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Apoptosis; Fungicide; Necrosis.
FT   PEPTIDE         1..13
FT                   /note="Periplanetasin-4"
FT                   /id="PRO_0000447997"
SQ   SEQUENCE   13 AA;  1505 MW;  18BE8B1D0AD7586B CRC64;
     LRHKVYGYCV LGP