PERI_BOVIN
ID PERI_BOVIN Reviewed; 469 AA.
AC A6QQJ3;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Peripherin;
GN Name=PRPH;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Class-III neuronal intermediate filament protein (By
CC similarity). May form an independent structural network without the
CC involvement of other neurofilaments or may cooperate with the neuronal
CC intermediate filament proteins NEFL, NEFH, NEFM and INA to form a
CC filamentous network (By similarity). Assembly of the neuronal
CC intermediate filaments may be regulated by RAB7A (By similarity). Plays
CC a role in the development of unmyelinated sensory neurons (By
CC similarity). May be involved in axon elongation and axon regeneration
CC after injury (By similarity). Inhibits neurite extension in type II
CC spiral ganglion neurons in the cochlea (By similarity).
CC {ECO:0000250|UniProtKB:P15331, ECO:0000250|UniProtKB:P21807}.
CC -!- SUBUNIT: Forms homodimers (in vitro) (By similarity). Homopolymerizes
CC into a filamentous network (in vitro) (By similarity). Forms
CC heterodimers with NEFL, NEFM or NEFH (in vitro) (By similarity).
CC Interacts with DST (via C-terminus) (By similarity). Interacts with
CC RAB7A; the interaction is direct (By similarity). Interacts with PRKCE
CC (via phorbol-ester/DAG-type 2 domain) (By similarity).
CC {ECO:0000250|UniProtKB:P15331, ECO:0000250|UniProtKB:P21807,
CC ECO:0000250|UniProtKB:P41219}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:P15331}. Cell projection, axon
CC {ECO:0000250|UniProtKB:P15331}. Perikaryon
CC {ECO:0000250|UniProtKB:P15331}.
CC -!- PTM: Phosphorylated; phosphorylation increases after nerve injury in
CC regenerating neurons. {ECO:0000250|UniProtKB:P21807}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; BC149862; AAI49863.1; -; mRNA.
DR RefSeq; NP_001095848.1; NM_001102378.1.
DR AlphaFoldDB; A6QQJ3; -.
DR SMR; A6QQJ3; -.
DR STRING; 9913.ENSBTAP00000023744; -.
DR PaxDb; A6QQJ3; -.
DR PeptideAtlas; A6QQJ3; -.
DR PRIDE; A6QQJ3; -.
DR Ensembl; ENSBTAT00000023744; ENSBTAP00000023744; ENSBTAG00000017864.
DR GeneID; 510082; -.
DR KEGG; bta:510082; -.
DR CTD; 5630; -.
DR VEuPathDB; HostDB:ENSBTAG00000017864; -.
DR VGNC; VGNC:33384; PRPH.
DR eggNOG; ENOG502QPSH; Eukaryota.
DR GeneTree; ENSGT00940000160203; -.
DR HOGENOM; CLU_012560_7_4_1; -.
DR InParanoid; A6QQJ3; -.
DR OMA; THSRKMV; -.
DR OrthoDB; 655109at2759; -.
DR TreeFam; TF330122; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000017864; Expressed in conceptus and 51 other tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045098; C:type III intermediate filament; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR InterPro; IPR002957; Keratin_I.
DR InterPro; IPR027700; PRPH/Plasticin.
DR PANTHER; PTHR45652:SF14; PTHR45652:SF14; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Coiled coil; Cytoplasm; Cytoskeleton;
KW Intermediate filament; Nitration; Phosphoprotein; Reference proteome.
FT CHAIN 1..469
FT /note="Peripherin"
FT /id="PRO_0000405805"
FT DOMAIN 96..406
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..98
FT /note="Head"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..131
FT /note="Coil 1A"
FT REGION 132..142
FT /note="Linker 1"
FT REGION 143..238
FT /note="Coil 1B"
FT REGION 239..261
FT /note="Linker 2"
FT REGION 262..404
FT /note="Coil 2"
FT REGION 405..469
FT /note="Tail"
FT /evidence="ECO:0000250"
FT REGION 447..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="3'-nitrotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P21807"
FT MOD_RES 27
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21807"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21807"
FT MOD_RES 58
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P15331"
FT MOD_RES 378
FT /note="3'-nitrotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P21807"
FT MOD_RES 469
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P21807"
SQ SEQUENCE 469 AA; 53631 MW; 4889823E57A0501A CRC64;
MSHPSGLRSS VSSTSYRRTF GPPPSLSPGA FSYSSSSRFS SSRLLGSASP GSSVRLGSFR
GPRAGTGALL RLPSERLDFS MAEALNQEFL ATRSNEKQEL QELNDRFANF IEKVRFLEQQ
NAALRGELNQ ARGQEPARAD QLCQQELREL RRELELLGRE RDRVQVERDG LAEDLAALKQ
RLEEETRKRE DAEHNLVLFR KDVDDATLSR LELERKIESL MDEIEFLKKL HEEELRDLQL
SVESQQVQHV EVEATVKPEL TAALRDIRAQ YESIAAKNLQ EAEEWYKSKY ADLSDAANRN
HEALRQAKQE MNESRRQIQS LTCEVDGLRG TNEALLRQLR ELEEQFALEA GGYQAGAARL
EEELRQLKEE MARHLREYQE LLNVKMALDI EIATYRKLLE GEESRISVPV HSFASLSIKT
TVPEVEPPQE THSRKMVLIR TIETRDGEQV VTESQKEQHS ELDKSPQSY
