ID   PERI_HYDVU              Reviewed;         158 AA.
AC   Q5Y8D6;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Periculin-1;
DE   AltName: Full=Hydraporin-1;
DE   Flags: Precursor;
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=16337937; DOI=10.1016/j.ydbio.2005.10.028;
RA   Genikhovich G., Kurn U., Hemmrich G., Bosch T.C.G.;
RT   "Discovery of genes expressed in Hydra embryogenesis.";
RL   Dev. Biol. 289:466-481(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=19013190; DOI=10.1016/j.dci.2008.10.004;
RA   Bosch T.C.G., Augustin R., Anton-Erxleben F., Fraune S., Hemmrich G.,
RA   Zill H., Rosenstiel P., Jacobs G., Schreiber S., Leippe M., Stanisak M.,
RA   Groetzinger J., Jung S., Podschun R., Bartels J., Harder J.,
RA   Schroeder J.-M.;
RT   "Uncovering the evolutionary history of innate immunity: the simple
RT   metazoan Hydra uses epithelial cells for host defence.";
RL   Dev. Comp. Immunol. 33:559-569(2009).
CC   -!- FUNCTION: Antibacterial peptide. May also be active against virus,
CC       since it is induced by dsRNA. {ECO:0000269|PubMed:19013190}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the endodermal epithelium and in some
CC       interstitial cells in the ectoderm. {ECO:0000269|PubMed:19013190}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryos and in adults.
CC       {ECO:0000269|PubMed:16337937}.
CC   -!- INDUCTION: By a wide variety of microbial and tissue components such as
CC       bacterial flagellin and lipopolysaccharides (LPS), dsRNA (reflecting an
CC       antiviral response), cell death signals, monosodium urate (MSU) (the
CC       end product of the urine catabolism, which is one of the principal
CC       endogenous immunological 'danger signal' in vertebrates).
CC       {ECO:0000269|PubMed:19013190}.
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DR   EMBL; AY649787; AAT72923.2; -; mRNA.
DR   AlphaFoldDB; Q5Y8D6; -.
DR   PRIDE; Q5Y8D6; -.
DR   Proteomes; UP000694840; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR002557; Chitin-bd_dom.
DR   Pfam; PF01607; CBM_14; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Antiviral defense; Disulfide bond; Immunity;
KW   Innate immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..158
FT                   /note="Periculin-1"
FT                   /id="PRO_0000394510"
FT   REGION          32..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        88..135
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..146
FT                   /evidence="ECO:0000255"
FT   DISULFID        128..153
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   158 AA;  18117 MW;  EBBBE37105F2D68D CRC64;
     MFMKIIFISS VIILAAADEF IESEDQYDLN INPPKEEYKN QYESNNEYQP TSEYNNNKKP
     SKTDYENQYE SSNKYQPKSG YKPKKVICLD IDVTKQCKNR ADGNYAIDNK PRAGYIACVN
     KSPICMPCPY GLTFCAKTGY KGLGHCLGEY DECQSRSY