ID   PERM1_BOVIN             Reviewed;         901 AA.
AC   A5D7L8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=PGC-1 and ERR-induced regulator in muscle protein 1;
DE   AltName: Full=PPARGC1 and ESRR-induced regulator in muscle 1;
DE   AltName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1;
GN   Name=PERM1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the expression of selective PPARGC1A/B and
CC       ESRRA/B/G target genes with roles in glucose and lipid metabolism,
CC       energy transfer, contractile function, muscle mitochondrial biogenesis
CC       and oxidative capacity. Required for the efficient induction of MT-CO2,
CC       MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively
CC       regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and
CC       SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression
CC       of PDK4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Shows a nuclear localization in the presence of PPARGC1A.
CC       {ECO:0000250}.
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DR   EMBL; BC140606; AAI40607.1; -; mRNA.
DR   RefSeq; NP_001091517.1; NM_001098048.1.
DR   RefSeq; XP_005217147.1; XM_005217090.3.
DR   RefSeq; XP_015330635.1; XM_015475149.1.
DR   AlphaFoldDB; A5D7L8; -.
DR   STRING; 9913.ENSBTAP00000008511; -.
DR   PaxDb; A5D7L8; -.
DR   Ensembl; ENSBTAT00000008511; ENSBTAP00000008511; ENSBTAG00000014540.
DR   GeneID; 520080; -.
DR   KEGG; bta:520080; -.
DR   CTD; 84808; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014540; -.
DR   VGNC; VGNC:32749; PERM1.
DR   eggNOG; ENOG502RYI7; Eukaryota.
DR   GeneTree; ENSGT00390000017652; -.
DR   HOGENOM; CLU_015049_0_0_1; -.
DR   InParanoid; A5D7L8; -.
DR   OMA; EVQWPDT; -.
DR   OrthoDB; 452214at2759; -.
DR   TreeFam; TF338365; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000014540; Expressed in choroid plexus and 85 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0014850; P:response to muscle activity; ISS:UniProtKB.
DR   InterPro; IPR043442; Perm1.
DR   PANTHER; PTHR47282; PTHR47282; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..901
FT                   /note="PGC-1 and ERR-induced regulator in muscle protein 1"
FT                   /id="PRO_0000299539"
FT   REGION          29..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          731..752
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..280
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..340
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..364
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..382
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..442
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..464
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..487
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   901 AA;  94210 MW;  9079FCE3DB31A306 CRC64;
     MENFQYSVQL SDQDWAEFSA AAEECGLLQA GLASGDEPLS SDTDQRDSRG SSPPGPSPFL
     EGQLTPGGSS WPSFEEEDKA ATRQLVSRSW HEPMLAPEAG QQTPSTSAQS EARLSLSPGA
     TPLVQGSSLP GPVSSRDEMQ RLLRGPAPRG PAPTPTGEPA GSPESPVHSA APQRSPGSPG
     APPRSPGRKK RRTAGTKAGG RSGGPGPAPT QLDSPLLTEA KPEDSFGPAG SRGKGLPAGA
     AKQTAGTGPE SAGAPEQVAG QGPGVDLSTS VSTTEQGTDR LGMSPRADPC AASTSDPGAP
     LDVTIKSDVA LSTPASEPQP DKPQSTPAFK PQPDEPQSTP AFKPQPDESQ STSAFNAQPN
     EPQSTPTFSP QPDEPQSTPA FKPQPDEPQS TSAFNAQPNE PQSTLAFSPQ PDEPQSTPAF
     KPQPDEPQST PAFNVQPNEP QSTPAFSPQP NEPQSTPAFK PQPDEPQSTP AFNTQPNEPQ
     STPTFKPRLD VDQLMPGPVV QPEVDSSMPA SKAVPCTALP HLVLEAGSDV GVSTPPAPTP
     QAGPDMVEAE VVPVAKLGLS PVRSLEGHQQ NPRGEPSTDA PGHHTGEPPL GPIQAPKKKK
     VRFSMAMPSS EEPGSGEVSG PLSPATAPRM ASGGHRGSGA WDSVAVGPRS PQPRILKHLP
     PPAPSASMGP GRRSCFAVTL PEAYDFFFCD TIEEEDEEAE GAAEAAQAPA EVQWPDVCEF
     FFQESQIQRS RHQEGRSQAP LLKAGSVPAP PPGDPMPISI PEAYEHFLEE DRSGGTLGPA
     ALLQMQATEP SRSVLWGVGT GAPPESSPAT VEQLTLAIRE AVAPRGPLTS FTFSQKDMCM
     VFVAFATWAV RTSDLHAPDA WKTVLLANIG TISAIRYFRR QVERGRHSRS RSPSPSSSPS
     P