ID   PERM_ECO57              Reviewed;         353 AA.
AC   P0AFJ0; P71230; P77406;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Putative permease PerM;
GN   Name=perM; OrderedLocusNames=Z3755, ECs3355;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC       family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57603.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36778.1; -; Genomic_DNA.
DR   PIR; C91048; C91048.
DR   RefSeq; NP_311382.1; NC_002695.1.
DR   RefSeq; WP_000892044.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AFJ0; -.
DR   STRING; 155864.EDL933_3648; -.
DR   EnsemblBacteria; AAG57603; AAG57603; Z3755.
DR   EnsemblBacteria; BAB36778; BAB36778; ECs_3355.
DR   GeneID; 66673642; -.
DR   GeneID; 915228; -.
DR   KEGG; ece:Z3755; -.
DR   KEGG; ecs:ECs_3355; -.
DR   PATRIC; fig|386585.9.peg.3504; -.
DR   eggNOG; COG0628; Bacteria.
DR   HOGENOM; CLU_031275_8_0_6; -.
DR   OMA; WRTLTAY; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002549; AI-2E-like.
DR   PANTHER; PTHR21716; PTHR21716; 1.
DR   Pfam; PF01594; AI-2E_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..353
FT                   /note="Putative permease PerM"
FT                   /id="PRO_0000148295"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   353 AA;  39194 MW;  E1CB8EB1E242FC3B CRC64;
     MLEMLMQWYR RRFSDPEAIA LLVILVAGFG IIFFFSGLLA PLLVAIVLAY LLEWPTVRLQ
     SIGCSRRWAT SIVLVVFVGI LLLMAFVVLP IAWQQGIYLI RDMPGMLNKL SDFAATLPRR
     YPALMDAGII DAMAENMRSR MLTMGDSVVK ISLASLVGLL TIAVYLVLVP LMVFFLLKDK
     EQMLNAVRRV LPRNRGLAGQ VWKEMNQQIT NYIRGKVLEM IVVGIATWLG FLLFGLNYSL
     LLAVLVGFSV LIPYIGAFVV TIPVVGVALF QFGAGTEFWS CFAVYLIIQA LDGNLLVPVL
     FSEAVNLHPL VIILSVVIFG GLWGFWGVFF AIPLATLIKA VIHAWPDGQI AQE