PERM_ECOLI
ID PERM_ECOLI Reviewed; 353 AA.
AC P0AFI9; P71230; P77406;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Putative permease PerM;
GN Name=perM; Synonyms=yfgO; OrderedLocusNames=b2493, JW2478;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 285-353.
RC STRAIN=K12;
RX PubMed=9387241; DOI=10.1099/00221287-143-11-3633;
RA Andrews S.C., Berks B.C., McClay J., Ambler A., Quail M.A., Golby P.,
RA Guest J.R.;
RT "A 12-cistron Escherichia coli operon (hyf) encoding a putative proton-
RT translocating formate hydrogenlyase system.";
RL Microbiology 143:3633-3647(1997).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC family. {ECO:0000305}.
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DR EMBL; U00096; AAC75546.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16382.1; -; Genomic_DNA.
DR EMBL; M63654; AAB88575.1; -; Genomic_DNA.
DR PIR; D65025; D65025.
DR RefSeq; NP_416988.1; NC_000913.3.
DR RefSeq; WP_000892044.1; NZ_STEB01000011.1.
DR AlphaFoldDB; P0AFI9; -.
DR BioGRID; 4261433; 30.
DR IntAct; P0AFI9; 1.
DR STRING; 511145.b2493; -.
DR TCDB; 2.A.86.1.1; the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9,b,22).
DR jPOST; P0AFI9; -.
DR PaxDb; P0AFI9; -.
DR PRIDE; P0AFI9; -.
DR DNASU; 945894; -.
DR EnsemblBacteria; AAC75546; AAC75546; b2493.
DR EnsemblBacteria; BAA16382; BAA16382; BAA16382.
DR GeneID; 66673642; -.
DR GeneID; 945894; -.
DR KEGG; ecj:JW2478; -.
DR KEGG; eco:b2493; -.
DR PATRIC; fig|1411691.4.peg.4246; -.
DR EchoBASE; EB3973; -.
DR eggNOG; COG0628; Bacteria.
DR HOGENOM; CLU_031275_8_0_6; -.
DR InParanoid; P0AFI9; -.
DR OMA; WRTLTAY; -.
DR PhylomeDB; P0AFI9; -.
DR BioCyc; EcoCyc:G7310-MON; -.
DR PRO; PR:P0AFI9; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR002549; AI-2E-like.
DR PANTHER; PTHR21716; PTHR21716; 1.
DR Pfam; PF01594; AI-2E_transport; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..353
FT /note="Putative permease PerM"
FT /id="PRO_0000148294"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 353 AA; 39194 MW; E1CB8EB1E242FC3B CRC64;
MLEMLMQWYR RRFSDPEAIA LLVILVAGFG IIFFFSGLLA PLLVAIVLAY LLEWPTVRLQ
SIGCSRRWAT SIVLVVFVGI LLLMAFVVLP IAWQQGIYLI RDMPGMLNKL SDFAATLPRR
YPALMDAGII DAMAENMRSR MLTMGDSVVK ISLASLVGLL TIAVYLVLVP LMVFFLLKDK
EQMLNAVRRV LPRNRGLAGQ VWKEMNQQIT NYIRGKVLEM IVVGIATWLG FLLFGLNYSL
LLAVLVGFSV LIPYIGAFVV TIPVVGVALF QFGAGTEFWS CFAVYLIIQA LDGNLLVPVL
FSEAVNLHPL VIILSVVIFG GLWGFWGVFF AIPLATLIKA VIHAWPDGQI AQE
