ID   PERR_ECOLI              Reviewed;         297 AA.
AC   Q57083;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=HTH-type transcriptional regulator PerR;
DE   AltName: Full=Peroxide resistance protein PerR;
GN   Name=perR; OrderedLocusNames=b0254, JW0244;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Loewen P.C., Switala J., Volkert M.R.;
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T.,
RA   Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S.,
RA   Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.;
RT   "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0
RT   - 6.0 min (189,987 - 281,416bp) region.";
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Apparent regulatory gene involved in peroxide resistance in
CC       stationary phase.
CC   -!- INTERACTION:
CC       Q57083; Q57083: perR; NbExp=3; IntAct=EBI-541993, EBI-541993;
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; U57080; AAB01994.1; -; Genomic_DNA.
DR   EMBL; U70214; AAB08673.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73357.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA77924.1; -; Genomic_DNA.
DR   PIR; F64750; F64750.
DR   RefSeq; NP_414788.1; NC_000913.3.
DR   RefSeq; WP_000770246.1; NZ_LN832404.1.
DR   AlphaFoldDB; Q57083; -.
DR   SMR; Q57083; -.
DR   BioGRID; 4259774; 3.
DR   BioGRID; 849791; 2.
DR   DIP; DIP-10463N; -.
DR   IntAct; Q57083; 6.
DR   STRING; 511145.b0254; -.
DR   PaxDb; Q57083; -.
DR   PRIDE; Q57083; -.
DR   DNASU; 945417; -.
DR   EnsemblBacteria; AAC73357; AAC73357; b0254.
DR   EnsemblBacteria; BAA77924; BAA77924; BAA77924.
DR   GeneID; 945417; -.
DR   KEGG; ecj:JW0244; -.
DR   KEGG; eco:b0254; -.
DR   PATRIC; fig|1411691.4.peg.2028; -.
DR   EchoBASE; EB3124; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_37_1_6; -.
DR   InParanoid; Q57083; -.
DR   OMA; CSYESIQ; -.
DR   PhylomeDB; Q57083; -.
DR   BioCyc; EcoCyc:G6129-MON; -.
DR   PRO; PR:Q57083; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..297
FT                   /note="HTH-type transcriptional regulator PerR"
FT                   /id="PRO_0000105743"
FT   DOMAIN          7..64
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        24..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   297 AA;  33639 MW;  E197CE2334B7420E CRC64;
     MKLLAKAPLN LLRAFEAAGR TGAFALAASE LELSPSAISH AIRKLENLLD VRLFQRSTRE
     ITLTKEGEIL LEHIQRGFNE LQQGLALVTA DESRPLRLHT APSFAHQWLL PRLGKFIREN
     PSIDLRLSAS TEYARFEQDD FDLDIVYGEP RPSPYEKIPL AVEELTPLCS PQLAERLKKP
     EDLYALTLIQ CDVQLYQWKG WFEANKMTPP NNYGLRFDRS FMAIAAAVDG LGVVLESKLL
     AEREIASGKL VCPLVNSTSE IHYIGHYLVF PQHQHMHSAL DVFKTWLLNE LNLGKIR