ID   PERR_STAES              Reviewed;         150 AA.
AC   Q8CNQ7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Peroxide-responsive repressor PerR;
GN   Name=perR; OrderedLocusNames=SE_1545;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Manganese-dependent repressor that controls a regulon of
CC       oxidative stress resistance and iron-storage proteins. May act as a
CC       hydrogen peroxide and organic hydroperoxide sensor (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO05144.1; -; Genomic_DNA.
DR   RefSeq; NP_765100.1; NC_004461.1.
DR   RefSeq; WP_001830391.1; NZ_WBME01000089.1.
DR   AlphaFoldDB; Q8CNQ7; -.
DR   SMR; Q8CNQ7; -.
DR   STRING; 176280.SE_1545; -.
DR   EnsemblBacteria; AAO05144; AAO05144; SE_1545.
DR   GeneID; 50018354; -.
DR   KEGG; sep:SE_1545; -.
DR   PATRIC; fig|176280.10.peg.1510; -.
DR   eggNOG; COG0735; Bacteria.
DR   HOGENOM; CLU_096072_4_2_9; -.
DR   OMA; YLYGVCT; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07153; Fur_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.1490.190; -; 1.
DR   InterPro; IPR002481; FUR.
DR   InterPro; IPR043135; Fur_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33202; PTHR33202; 1.
DR   Pfam; PF01475; FUR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Manganese; Metal-binding; Repressor; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..150
FT                   /note="Peroxide-responsive repressor PerR"
FT                   /id="PRO_0000289019"
FT   REGION          1..84
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   BINDING         102
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         105
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         142
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         145
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   150 AA;  17280 MW;  780BD8F9B170F2A8 CRC64;
     MSAELESIDH ELEESIASLR KAGVRITPQR QAIMRYLISS HSHPTADEIY QALSPKFPNI
     SVATIYNNLR VFKDIGIVKE LTYGDSSSRF DFNTHNHYHI ICEKCGKIVD FHYPQLDEVE
     QLAQHVTDFD VTHHRMEIYG VCKECKEEGN