ID   PER_ANTPE               Reviewed;         849 AA.
AC   Q17062;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Period circadian protein;
GN   Name=per;
OS   Antheraea pernyi (Chinese oak silk moth) (Bombyx pernyi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Saturniinae; Saturniini; Antheraea.
OX   NCBI_TaxID=7119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Head, and Thorax;
RX   PubMed=7946353; DOI=10.1016/0896-6273(94)90054-x;
RA   Reppert S.M., Tsai T., Roca A.L., Sauman I.;
RT   "Cloning of a structural and functional homolog of the circadian clock gene
RT   period from the giant silkmoth Antheraea pernyi.";
RL   Neuron 13:1167-1176(1994).
CC   -!- FUNCTION: Involved in the generation of biological rhythms. The
CC       biological cycle depends on the rhythmic formation and nuclear
CC       localization of the tim-per complex. Light induces the degradation of
CC       tim, which promotes elimination of per. Nuclear activity of the
CC       heterodimer coordinatively regulates per and tim transcription negative
CC       feedback loop. Behaves as a negative element in circadian
CC       transcriptional loop. Does not appear to bind DNA, suggesting indirect
CC       transcriptional inhibition (By similarity). Expression exhibits
CC       prominent circadian variation in adult heads and in particular in the
CC       photoreceptor nuclei. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with timeless (TIM); the complex then
CC       translocates into the nucleus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Nuclear at specific periods of the
CC       day. Interaction with TIM is required for nuclear localization (By
CC       similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated with a circadian rhythmicity. {ECO:0000250}.
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DR   EMBL; U12769; AAA64675.1; -; mRNA.
DR   AlphaFoldDB; Q17062; -.
DR   SMR; Q17062; -.
DR   PRIDE; Q17062; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd00130; PAS; 2.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   Pfam; PF00989; PAS; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55785; SSF55785; 2.
DR   PROSITE; PS50112; PAS; 2.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Nucleus; Phosphoprotein; Repeat.
FT   CHAIN           1..849
FT                   /note="Period circadian protein"
FT                   /id="PRO_0000162616"
FT   DOMAIN          166..296
FT                   /note="PAS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DOMAIN          314..416
FT                   /note="PAS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..746
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           63..74
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..704
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        716..746
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  94799 MW;  07C8654EEC058770 CRC64;
     MNNMDGSENN AKVSDSAYSN SCSNSQSRRS HSSKSTHSGS NSSGSSGYGG QPSTSSSSND
     LSDQKKEKEL KKKKQVETLM PDTQIEVECR PEEDVINIPS EEGGAADDVL VPSPKQTLQT
     DNDIADIEVA IPDTNNDKEE AIVYNTSLIN PGTACPFGRP ALSNCNGFSC VISMHDGVVL
     YATASLTSTL GFPKDMWVGR SFIDFVHPRD RNTFASQITN ELAIPKIVSL TEETDQTMEN
     PGSTMVCRIR RYRGLSCGFS VKNTTTAYLP FLLKFKFKNV NEDKGNVIYL VIQAVPFFSA
     FKTSNEVLAK TVSFVIRHSA DGNLEYIDAE SVPYLGYLPQ DITNRDALLL YHPGDLGYLQ
     EIYGSLVKEG NVTRSKTYRM MTQNGHYMKV ETEWSAFINP WSKKLEFVTG KHYIIEGPAN
     PDVFQNPENV LKLTEEQKNQ AKMYRDSIIR IMKDVLTKPA EIAKQQMSKR CQDLAHFMEM
     LIEEQPKPVD DLRLEIQDAD HSYYERDSVI LGGISPHHEY DSKSSTETPL SYNQLNYNDN
     LQRYFNSHQS NAFVDNNLLP SRNPLYLSAP HFSESIKNVP SAMEYSGDVI DLTGPGETSG
     VIVFNKSPTM GLKTGKPIRL TESSLTKHNA EMEKELMKIH REHRCYSKGD RVKVSNEARQ
     KKKEHLARCN AGFQTISAAN NTPSVYEKPH NLKRSSKQME SEPIANKHHC PSSRQFRRKQ
     TTCSGGFAQP PSATNPVSTS SQWSSSPVNN VNPFILGVRM QPPMPILSPL PVVSGMFPMY
     YTPVTATVTT SEGRPSEPNY HRNNMNNNQF QQPLGNSRLP TTICVIQCGT SRIIHSFRGT
     RTTGGTRYT