PES1_CAEBR
ID PES1_CAEBR Reviewed; 310 AA.
AC Q9GZ14; H8WHB6; Q9GZ12; Q9GZ13;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Forkhead box protein pes-1 {ECO:0000250|UniProtKB:G5EGC9};
DE AltName: Full=Pattern expression site 1 {ECO:0000250|UniProtKB:G5EGC9};
GN Name=pes-1 {ECO:0000312|WormBase:CBG24736};
GN ORFNames=CBG24736 {ECO:0000312|WormBase:CBG24736};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000312|Proteomes:UP000008549};
RN [1] {ECO:0000312|EMBL:AAF99288.1, ECO:0000312|EMBL:AAF99289.1, ECO:0000312|EMBL:AAF99290.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-181 AND 204-276 (ISOFORMS 1 AND 2),
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=11044397; DOI=10.1242/dev.127.22.4825;
RA Molin L., Mounsey A., Aslam S., Bauer P., Young J., James M.,
RA Sharma-Oates A., Hope I.A.;
RT "Evolutionary conservation of redundancy between a diverged pair of
RT forkhead transcription factor homologues.";
RL Development 127:4825-4835(2000).
RN [2] {ECO:0000312|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000312|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Transcription factor (By similarity). Plays a role in
CC embryogenesis and later development, perhaps acting redundantly with
CC forkhead protein fkh-2 (PubMed:11044397).
CC {ECO:0000250|UniProtKB:Q12952, ECO:0000269|PubMed:11044397}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC Cytoplasm {ECO:0000250|UniProtKB:G5EGC9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9GZ14-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9GZ14-2; Sequence=VSP_061493;
CC -!- DEVELOPMENTAL STAGE: Expressed in the AB lineage at the 185 cell stage
CC (PubMed:11044397). Also expressed in the lineage of the D founder cell
CC in the 185 cell embryo, continuing to at least the comma stage
CC (PubMed:11044397). Expressed in Z1 and Z4 cells at the comma stage
CC (PubMed:11044397). {ECO:0000269|PubMed:11044397}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in adults has little or
CC no phenotypic effect on adult or their progeny (PubMed:11044397).
CC However, simultaneous knockdown of forkhead gene fkh-2 in adults causes
CC 8% embryonic lethality, and nearly 80% arrest after hatching as L1
CC stage larvae (PubMed:11044397). {ECO:0000269|PubMed:11044397}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CCG58537.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF260299; AAF99288.1; -; mRNA.
DR EMBL; AF260300; AAF99289.1; -; mRNA.
DR EMBL; AF260301; AAF99290.1; -; mRNA.
DR EMBL; HE601487; CCG58537.1; ALT_SEQ; Genomic_DNA.
DR STRING; 6238.CBG24736; -.
DR EnsemblMetazoa; CBG24736.1; CBG24736.1; WBGene00042778.
DR WormBase; CBG24736; CBP37858; WBGene00042778; Cbr-pes-1.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_099179_0_0_1; -.
DR InParanoid; Q9GZ14; -.
DR OMA; KMENGGW; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000008549; Chromosome IV.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..310
FT /note="Forkhead box protein pes-1"
FT /id="PRO_0000455412"
FT DNA_BIND 128..220
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..37
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_061493"
SQ SEQUENCE 310 AA; 33824 MW; 2847874086177AE7 CRC64;
MLPLSISTSP DPASQFPTVP DLPTLTPTPS PTSGTAKMNE FTISNLCPEA SDRLSLEVSP
SSTGLLEPKS STVSPAPSCT GYPIFDLTGI SKQSSSGVSS TRTSSLEPKS SAVSPAPSSP
EASNPNKRPA YSYNALIAMA IQNSPFKALR LSEIYAYISN NFPYYKMENG GWQNSIRHNL
SLREEFYKVQ TTDGKGSFWA MNTQLGSDVY IGKDCGSLRR KKNGKPRKYS KRSNTVSNPN
PIPQIPSFTP SPLLATPFPL FLYISQAYAQ NPNLLPMMLQ NFQHFNFQNI PALSFPFPFS
NSNGNPNSRN
