PES1_CAEEL
ID PES1_CAEEL Reviewed; 264 AA.
AC G5EGC9; Q7JMT8;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Forkhead box protein pes-1 {ECO:0000305};
DE AltName: Full=Pattern expression site 1 {ECO:0000303|PubMed:8162851};
GN Name=pes-1 {ECO:0000312|WormBase:T28H11.4a};
GN ORFNames=T28H11.4 {ECO:0000312|WormBase:T28H11.4a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:CAA82224.1, ECO:0000312|EMBL:CAA82225.1, ECO:0000312|EMBL:CAA82226.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:CAA82224.1,
RC ECO:0000312|EMBL:CAA82225.1, ECO:0000312|EMBL:CAA82226.1};
RX PubMed=8162851; DOI=10.1242/dev.120.3.505;
RA Hope I.A.;
RT "PES-1 is expressed during early embryogenesis in Caenorhabditis elegans
RT and has homology to the fork head family of transcription factors.";
RL Development 120:505-514(1994).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP DEVELOPMENTAL STAGE.
RX PubMed=9872954; DOI=10.1093/genetics/151.1.131;
RA Molin L., Schnabel H., Kaletta T., Feichtinger R., Hope I.A., Schnabel R.;
RT "Complexity of developmental control: analysis of embryonic cell lineage
RT specification in Caenorhabditis elegans using pes-1 as an early marker.";
RL Genetics 151:131-141(1999).
RN [4] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11044397; DOI=10.1242/dev.127.22.4825;
RA Molin L., Mounsey A., Aslam S., Bauer P., Young J., James M.,
RA Sharma-Oates A., Hope I.A.;
RT "Evolutionary conservation of redundancy between a diverged pair of
RT forkhead transcription factor homologues.";
RL Development 127:4825-4835(2000).
CC -!- FUNCTION: Transcription factor (By similarity). Plays a role in
CC embryogenesis and later development, perhaps acting redundantly with
CC forkhead protein fkh-2 (PubMed:11044397).
CC {ECO:0000250|UniProtKB:Q12952, ECO:0000269|PubMed:11044397}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089,
CC ECO:0000269|PubMed:8162851}. Cytoplasm {ECO:0000269|PubMed:8162851}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:T28H11.4a};
CC IsoId=G5EGC9-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:T28H11.4b};
CC IsoId=G5EGC9-2; Sequence=VSP_061478;
CC -!- DEVELOPMENTAL STAGE: First expressed during embryogenesis in the AB
CC lineage, as the lineage increases from 16 to 32 cells (PubMed:8162851,
CC PubMed:9872954). Expression in the AB lineage diminishes around the 168
CC cell embryo stage and the expression pattern becomes symmetrical about
CC the embryo's plane of bilateral symmetry (PubMed:8162851,
CC PubMed:9872954). Also expressed in the lineage of the D founder cell
CC initially in the 100 cell embryo (PubMed:8162851, PubMed:9872954). As
CC embryonic elongation commences, expressed in Z1 and Z4 cells; this
CC expression increases during the rest of embryogenesis and disappears
CC shortly after hatching (PubMed:8162851). Expressed in the MS lineage,
CC specifically in MSaaa and MSaap at the 51-cell stage (PubMed:9872954).
CC {ECO:0000269|PubMed:8162851, ECO:0000269|PubMed:9872954}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown by injection into adults
CC has little or no phenotypic effect (PubMed:11044397). However,
CC simultaneous knockdown of forkhead gene fkh-2 causes 12% of eggs
CC produced by hermaphrodites to arrest development at late stages of
CC embryogenesis and 81% arrest after hatching as L1 stage larvae
CC (PubMed:11044397). {ECO:0000269|PubMed:11044397}.
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DR EMBL; Z28375; CAA82224.1; -; Genomic_DNA.
DR EMBL; Z28376; CAA82225.1; -; mRNA.
DR EMBL; Z28377; CAA82226.1; -; mRNA.
DR EMBL; BX284604; CCD63837.1; -; Genomic_DNA.
DR EMBL; BX284604; CCQ25698.1; -; Genomic_DNA.
DR PIR; S42793; S42793.
DR RefSeq; NP_001023406.1; NM_001028235.1.
DR RefSeq; NP_001263750.1; NM_001276821.1.
DR AlphaFoldDB; G5EGC9; -.
DR SMR; G5EGC9; -.
DR IntAct; G5EGC9; 1.
DR STRING; 6239.T28H11.4a; -.
DR PaxDb; G5EGC9; -.
DR EnsemblMetazoa; T28H11.4a.1; T28H11.4a.1; WBGene00003976. [G5EGC9-1]
DR EnsemblMetazoa; T28H11.4b.1; T28H11.4b.1; WBGene00003976. [G5EGC9-2]
DR GeneID; 177267; -.
DR KEGG; cel:CELE_T28H11.4; -.
DR CTD; 177267; -.
DR WormBase; T28H11.4a; CE14375; WBGene00003976; pes-1.
DR WormBase; T28H11.4b; CE48175; WBGene00003976; pes-1.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162075; -.
DR HOGENOM; CLU_099179_0_0_1; -.
DR InParanoid; G5EGC9; -.
DR OMA; SFHTRSE; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; G5EGC9; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003976; Expressed in embryo and 3 other tissues.
DR ExpressionAtlas; G5EGC9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IGI:WormBase.
DR GO; GO:0002119; P:nematode larval development; IGI:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..264
FT /note="Forkhead box protein pes-1"
FT /id="PRO_0000455281"
FT DNA_BIND 93..186
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 15..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..36
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:8162851"
FT /id="VSP_061478"
SQ SEQUENCE 264 AA; 29481 MW; E682DA8426D3C7CF CRC64;
MTSSIKSDAP QFLLDLDNCS SLPPTPPKTA SPGNSKMKGF NISDLCLDLD SSTSSSCSVS
PASSFHTRSE SVGQQQSGRN SPVSSSTESP TKRPKYSYNA LIAMAIQSSP FKSLRVSEIY
KYISSNFSYY KNQKPLQWQN SVRHNLSLHK EFRKVRTLDG KGSYWAMTAD LGTDVYISNN
CGKLRRQKSK VAKFPPMQQH FPIPQLPTQN IHQLCMQNPQ ILATLLQNMY LQNMQNLQNI
PMVPGFPIIP VPINPTSFHF PKSS
